The effect of silymarin on liver injury induced by Thioacetamide in rats

Kabiri, najmeh. and Ahangar Darabi, Mahboobeh. and Setorki, Mahbubeh. and Rafieian-Kopaei, Mahmoud. (2013) The effect of silymarin on liver injury induced by Thioacetamide in rats. Journal of HerbMed Pharmacology, 2.

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Abstract

<p><strong>Introduction:</strong> In this study the protective effects of Silymarin was investigated against thioacetamide (TAA) induced hepatotoxicity in rat. </p> <p> <strong>Methods:</strong> In an experimental study 24 male Wistar rats were designated in four equal groups as follows: Control group, the group treated with thioacetamide (TAA), Silymarin (400 mg/kg for 3 weeks) + TAA (400 mg/kg), TAA (400 mg/kg) + Silymarin (400 mg/kg for 3 weeks). The levels of serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) lactate dehydrogenase (LDH) and total bilirubin were measured to assess the hepatotoxicity and hepatoprotection. </p> <p>Re<strong>sults: </strong>TAA significantly increased AST, ALT, ALP, LDH and bilirubin. Treatment by Silymarin caused a significant reduction in serum levels of AST, ALT, ALP, LDH and bilirubin contents.</p> <p> <strong>Conclusion: </strong>The results indicate a protective effect for Silymarin against thioacetamide induced hepatotoxicity which might be due to its ability to block the bioactivity of thioacetamide.</p>

Item Type: Article
Uncontrolled Keywords: Hepatoprotection Thioacetamide Silymarin Rat
Subjects: QV pharmacology > QV 704 Pharmaceutics
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: Users 1 not found.
Date Deposited: 11 Sep 2017 05:30
Last Modified: 06 Mar 2018 10:15
URI: http://eprints.skums.ac.ir/id/eprint/4807

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