Reversal effect of <em>Achillea millefolium </em>extract on ileum contractions

Sedighi, M. and Nasri, H. and Rafieian-Kopaei, M. and Mortazaei, S. (2013) Reversal effect of <em>Achillea millefolium </em>extract on ileum contractions. Journal of HerbMed Pharmacology, 2.

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Abstract

<p><strong>Introduction:</strong> Traditionally Achillea millefolium L. has been used to treat gastrointestinal disorders. In this study the hydroalcoholic extract of A. millefolium was evaluated on ileum contractions of Wistar rats. </p> <p><strong>Materials and Methods:</strong> In this experimental study 32 male Wistar rats were designated into 4 equal groups, including: acetyl choline, KCl, extract plus acetyl choline and the group which received extract plus KCl. The isotonic contractions of ileum (induced by 60 mM KCl or 1 &mu;M acetyl choline) in tyrode solution were recorded, under 1 gr tension. Then, the effects of normal saline or extract (1) were evaluated. The percentage changes were calculated and compared in different groups using ANOWA and Tukey tests. </p> <p> <strong>Results:</strong> The mean of ileum contractions in acetyl choline and KCl groups were 18.83&plusmn;4.91 and 18.31&plusmn;11.12 (p=0.5). The percentage of contraction relieve in extract plus acetyl choline group was 53.16&plusmn;12.06 and in extract plus KCl group was 62.96&plusmn;11.08 (p=0.4). The contractions in extract groups were significantly less than acetyl choline or KCl groups (p&lt;0.05). </p> <p> <strong>Conclusion:</strong> The results indicate that Achillea millefolium extract inhibits ileum contractions. Therefore, it might be used in patients to reduce ileum spasms.</p>

Item Type: Article
Uncontrolled Keywords: Achillea millefolium Ileum Ileum contraction Spasm
Subjects: WI Digestive System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: zahra bagheri .
Date Deposited: 11 Sep 2017 05:03
Last Modified: 11 Sep 2017 05:03
URI: http://eprints.skums.ac.ir/id/eprint/4793

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