Antifungal effects of Zataria multiflora and Nigella sativa extracts against Candida albicans

Moghim, Hassan. and Taghipoor, Simin. and Shahinfard, Najmeh. and Kheiri, Soleiman. and Panahi, Ramin. (2015) Antifungal effects of Zataria multiflora and Nigella sativa extracts against Candida albicans. Journal of Herbmed Pharmacology, 4.


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Introduction: Candidiasis is a fungal infection caused by Candida albicans. Recentstudies suggest that the side effects of herbal drugs with significant therapeutic effectsare far less than chemical drugs. This study was therefore, conducted to examineantifungal activities of Zataria multif lora and Nigella sativa extracts on C. albicans.Methods: Powders of Z. multif lora and N. sativa were macerated with ethanol 70 and evaporatedat 38˚C by rotary evaporator. The suspension of C. albicans was prepared according to McFarlandat a concentration of approximately 0.5-2.5 × 10CFU/ml. Testing was performed according tomicrobroth dilution in 96-well micro-dilution plates. Minimum inhibitory concentration (MIC),MIC50, MIC90 and minimum fungicidal concentration (MFC) were separately evaluated bycounting the fungal colonies for Z. multif lora and N. sativa.Results: The measured values of MIC, MIC50, MIC90 and MFC of Z. multiflora on the C.albicans were 0.13, 0.38, 0.74 and 1.03 mg/ml, and those of N. sativa were 10, 27.7, 52.3 and 72.3 mg/ml, respectively.Conclusion: The results indicate that both Zataria multiflora and Nigella sativa extracts are effectiveagainst Candida albicans, but the former species has the highest antifungal activity. If the clinicaltrials confirm the results of this study, Z. multiflora, as a new antifungal agent by replacing chemicaldrugs can be used to develop antifungal medicinal herbs.

Item Type: Article
Uncontrolled Keywords: Candida albicans,Zataria multiflora,Nigella sativa
Subjects: WC Communicable Diseases > Infection.Bacterial Infections
QV pharmacology > QV 752 Pharmacognosy
QW Microbiology and Immunology
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: Users 1 not found.
Date Deposited: 10 Sep 2017 06:08
Last Modified: 07 Apr 2018 05:48

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