The effect of gallic acid on Jurkat cell line

Sourani, Zahra. and Pourgheysari, Batoul. and Rafieian-Kopaei, Mahmoud. and shirzad, Hedayatollah. and Shirzad, Moein. (2015) The effect of gallic acid on Jurkat cell line. Journal of Herbmed Pharmacology, 4.


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Introduction: Acute lymphoblastic leukemia (ALL) is the most prevalent leukemia in children.Fruits and plants have a wide range of biological functions including anti-proliferative effect. Gallicacid (GA), is a polyhydroxyphenolic compound that is widely distributed in the natural plants. Theaim of the present study was the evaluation of the effect of GA on proliferation inhibition of Jurkatcells, the lymphoblastic leukemia cell line. Methods: Jurkat cell line was cultured in blood cells culture media in a standard conditions with different concentrations of GA (0-100 µm) for 24, 48 and 72 hours. The effect of GA on cell viabilitywas measured using MTS assay.Results: Decline of cell viability to less than 50 was observed at 60, 50 and 30 µm concentrationsafter 24, 48 and 72 hours incubation time, respectively.Conclusion: The results demonstrated that the polyphenolic compound, GA with antioxidantcapability is effective in proliferation inhibition in Jurkat lymphoblastic leukemia cell line witha time and dose dependent manner. Therefore, GA may be a potential compound for cancerprevention and treatment.

Item Type: Article
Uncontrolled Keywords: Gallic acid,Jurkat cell line,Acute lymphoblastic leukemia,Proliferation
Subjects: WH Hemic and Lymphatic System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: zahra bagheri .
Date Deposited: 10 Sep 2017 06:16
Last Modified: 15 Apr 2018 10:15

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