The relaxant effect of <em>Ferula assafoetida</em> on smooth muscles and the possible mechanisms

Khazdair, M.R. and Boskabady, M.H. (2015) The relaxant effect of <em>Ferula assafoetida</em> on smooth muscles and the possible mechanisms. Journal of HerbMed Pharmacology, 4.


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Asafoetida (<em>Ferula asafoetida</em>) an oleo-gum-resin belongs to the Apiaceae family which obtained from the living underground rhizome or tap roots of the plant. <em>F. assa-foetida</em> is used in traditional medicine for the treatment of variety of disorders. Asafoetida is used as a culinary spice and in folk medicine has been used to treat several diseases, including intestinal parasites, weak digestion, gastrointestinal disorders, asthma and influenza. A wide range of chemical compounds including sugars, sesquiterpene coumarins and polysulfides have been isolated from this plant. This oleo-gum-resin is known to possess antifungal, anti-diabetic, anti-inflammatory, anti-mutagenic and antiviral activities. Several studies investigated the effects of<em> F. asafoetida</em> gum extract on the contractile responses induced by acetylcholine, methacholin, histamine and KCl on different smooth muscles. The present review summarizes the information regarding the relaxant effect of asafetida and its extracts on different smooth muscles and the possible mechanisms of this effect.

Item Type: Article
Uncontrolled Keywords: Ferula asafoetida Extract Oleo-gum-resin Smooth muscle Relaxant effect
Subjects: WE Musculoskeletal system
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: Users 1 not found.
Date Deposited: 10 Sep 2017 09:07
Last Modified: 10 Sep 2017 09:07

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