Histomorphometric study on the effects of <em>Artemisia sieberi</em> extract in mice skin

Kaboutari, Jahangir. and Haydarnejad, Mohammad Saeed. and Fatahian Dehkordi, Rahmat allah. and Raeisi Vanani, Sedigheh. (2015) Histomorphometric study on the effects of <em>Artemisia sieberi</em> extract in mice skin. Journal of HerbMed Pharmacology, 4.

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Official URL: http://www.herbmedpharmacol.com/Abstract/JHP_20150...

Abstract

<p><strong>Introduction:</strong> Skin as the biggest single body organ is always exposing to various injuries, therefore health and healing of its injuries is vital. <em>Artemisia sieberi</em> is a valuable medicinal plant with a long history of indication in folk and modern medicine. Due to different chemical components and antioxidant, anti-inflammatory, antimicrobial and cytoprotective properties of Artemisia, this study was conducted to study the histomorphometric effects of <em>Artemisia sieberi (A. sieberi)</em> extract on mice skin.</p> <p><strong>Methods:</strong> Ninety adult mice were randomly divided in 3 groups. In the treatment group A. sieberi extract dissolved in ethanol &amp; distilled water, in the positive control ethanol &amp; distilled water, and in negative control only distilled water were applied on the shaved dorsum twice daily for 21 days. Mean thickness of epidermis, hypodermis &amp; dermis layers, percentage of collagen fibers and histological evaluation of skin layers were studied in 1, 3, 5, 14 and 21days post treatment. Data were presented as mean&plusmn; SD and analyzed using one way ANOVA and LSD post hoc tests. The P&lt;0.05 was considered as statistically significant.</p> <p><strong>Results:</strong> <em>A. sieberi </em>extract significantly increased epidermis thickness in day 1, hypodermis, dermis and percentage of collagen fibers in day 3 in comparison to positive and negative control groups. Histology study revealed normal structure of skin and no abnormality was seen.</p> <p><strong>Conclusion:</strong> <em>A. sieberi</em> extract can be effective for health and healing of skin injuries by increasing thickness of the skin layers and amount of collagen fibers.</p>

Item Type: Article
Uncontrolled Keywords: Artemisia sieberi Histomorphometry Skin
Subjects: WR Dermatology
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: Users 1 not found.
Date Deposited: 10 Sep 2017 08:16
Last Modified: 06 Mar 2018 10:19
URI: http://eprints.skums.ac.ir/id/eprint/4744

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