Catecholamines are active plant-based drug compounds in Pisum sativum, Phaseolus vulgaris and Vicia faba Species

Khozaei, M. and Ghorbani, F. and Mardani, G. and Emamzadeh, R. (2014) Catecholamines are active plant-based drug compounds in Pisum sativum, Phaseolus vulgaris and Vicia faba Species. Journal of HerbMed Pharmacology, 3.

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Abstract

<p><strong>Introduction:</strong> Catecholamines (L-DOPA and dopamine) are the key metabolites found in nervous system and their endogenous deficiency is associated with different patho-physiological disorders. Therefore, it is important to screen the new herbal sources of catecholamines for drug preparation. In this study, the amount of L-DOPA and dopamine were investigated in the leaves and roots of three species from legume family such as <em>Pisum sativum (garden pea), Phaseolus vulgaris (haricot bean) </em>and <em>Vicia faba (broad bean)</em>; using TLC and HPLC.</p> <p><strong>Methods:</strong> The seeds of <em>P. sativum, P. Vulgaris</em> and <em>V. faba</em> were treated and cultured under the glasshouse conditions. The extraction from 1 gram of each plant sample was obtained and assayed for L-DOPA and dopamine using thin layer chromatography (TLC) and reversed-phase HPLC.</p> <p><strong>Results: </strong>The results indicated that all cultivars accumulated different levels of L-DOPA and dopamine in leaves and roots. The quantitative results showed that the metabolites concentrations were high in the leaves of <em>P. Sativum </em>and <em>V. faba</em> compared to that in roots.</p> <p><strong>Conclusion:</strong> The present study may provide a new avenue for preparation and estimation of L-DOPA and dopamine from plant sources and may be used for further analysis and therapeutic studies.</p>

Item Type: Article
Uncontrolled Keywords: L-DOPA Dopamine HPLC Herbal medicine Catecholamines
Subjects: QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: zahra bagheri .
Date Deposited: 10 Sep 2017 06:58
Last Modified: 10 Sep 2017 06:58
URI: http://eprints.skums.ac.ir/id/eprint/4728

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