Evaluation of antidepressant-like effect of hydroalcoholic extract of Passiflora incarnata in animal models of depression in male mice

Jafarpoor, N. and Abbasi-Maleki, S. and Asadi-Samani, M. and Khayatnouri, M.H. (2014) Evaluation of antidepressant-like effect of hydroalcoholic extract of Passiflora incarnata in animal models of depression in male mice. Journal of HerbMed Pharmacology, 3.

[img]
Preview
Text
23.pdf

Download (468kB) | Preview
Official URL: http://www.herbmedpharmacol.com/Abstract/JHP_20150...

Abstract

<p><strong>Introduction:</strong><em> Passiflora incarnata </em>(PI) is one of the commonest herbal anti-anxiety and sedative agents. The aim of the present study was to investigate the antidepressant effect of hydroalcoholic extract of PI in forced swim test (FST) and tail suspension test (TST) in male mice.</p> <p><strong>Methods: </strong>In this experimental study, 48 male mice were randomly divided into 6 groups of 8: Negative and positive control groups received normal saline (10 ml/kg), fluoxetine (20 mg/kg) and imipramine (30 mg/kg), respectively and treatment groups received extracts of PI (200, 400 and 800 mg/kg). Immobility, swimming and climbing behaviors were recorded during 6-min. </p> <p> <strong>Results: </strong>All doses of PI extract compared to control group significantly reduced the duration of immobility time in both of two tests (p&lt;0.001). Also, these extracts increased swimming time (p&lt;0.001) without significant change of climbing time. </p> <p><strong>Conclusion:</strong> PI has considerable antidepressant-like effect in animal models of depression. However, further studies are needed to determine its exact mechanism of action.</p>

Item Type: Article
Uncontrolled Keywords: Passiflora incarnata Hydroalcoholic extract Forced swim test Tail suspension test Mice
Subjects: WM Psychiatry
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: zahra bagheri .
Date Deposited: 10 Sep 2017 06:49
Last Modified: 10 Sep 2017 06:49
URI: http://eprints.skums.ac.ir/id/eprint/4724

Actions (login required)

View Item View Item