<p style="margin: 0cm 0cm 8pt; text-align: center; line-height: normal;">Virucidal potential of Prosopis spicigera and Mangifera indica on human peripheral blood mononuclear cells</p>

Gupta, A. and Chaphalkar, S. (2016) <p style="margin: 0cm 0cm 8pt; text-align: center; line-height: normal;">Virucidal potential of Prosopis spicigera and Mangifera indica on human peripheral blood mononuclear cells</p>. Journal of Herbmed Pharmacology, 5.

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Abstract

<p style="margin: 0cm 0cm 0pt; text-align: justify; line-height: normal;">Introduction: The treatment of viral infections with the available antiviral drugs is not free of side effects. Therefore, in the present study, our group focused on antiviral activity against Newcastle disease (NDV) and IBD viruses using medicinal plants especially leaves of Prosopis spicigera and Mangifera indica.Methods: Different medicinal plant products especially leaves of P. spicigera and M. indica were tested in the form of aqueous leaves extracts (0.5- 30 mg/mL; 50 &mu;L) for anti-microbial activities on human peripheral blood mononuclear cells (PBMC) pertaining to determine their proliferation rate (cytotoxicity assay), tumor necrosis factor alpha (TNF&alpha;) production and CD14 monocyte surface marker.Results: Three medicinal plant aqueous extracts showed significant antimicrobial activity against PBMC at higher doses with respect to decline in proliferation assay, TNF&alpha; production and CD14 monocyte surface marker as compared to control.Conclusion: Aqueous leaves extract of P. spicigera and M. indica showed antimicrobial activities and might be useful for the treatment of various viral diseases.</p>

Item Type: Article
Uncontrolled Keywords: Mangifera indica,Prosopis spicigera,Anti-microbial,PBMC
Subjects: WC Communicable Diseases > Infection.Bacterial Infections
QV pharmacology > QV 752 Pharmacognosy
QW Microbiology and Immunology
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: zahra bagheri .
Date Deposited: 06 Sep 2017 09:44
Last Modified: 11 Sep 2017 03:09
URI: http://eprints.skums.ac.ir/id/eprint/4706

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