Antibacterial activity and ciprofloxacin-potentiation property of Berberis vulgaris asperma stem extracts on pathogenic bacteria

Ebrahimi, A. and Chavoshpour, M. and Mahzoonieh, M.R. and Lotfalian, Sh. (2016) Antibacterial activity and ciprofloxacin-potentiation property of Berberis vulgaris asperma stem extracts on pathogenic bacteria. Journal of Herbmed Pharmacology, 5.

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Abstract

Introduction: This study was planned to search the antibacterial activities of the ethanol and Chloroform extracts of Berberis vulgaris asperma stem and their synergistic effects with ciprofloxacin against some gram-negative pathogenic bacteria.Methods: Broth micro-dilution method was used for determination of minimum inhibitory concentrations (MICs) of the extracts alone or in association with ciprofloxacin and Phenylalanine-Arginine β-Naphtylamide (PAβN) as a positive control and efflux pumps inhibitor (EPI).Results: MIC determination indicated that the extracts from Berberis vulgaris asperma stem were able to inhibit the growth of all the studied bacteria within a concentration range of 3900 to 37500 μg/mL. Synergistic effects were noted between the extracts from Berberis vulgaris asperma stem extracts and ciprofloxacin on all tested bacteria except Acinetobacter bummani.Conclusion: Berberis vulgaris asperma stem extracts act as an antibacterial agent and potentiate ciprofloxacin effects on examined pathogenic bacteria.

Item Type: Article
Uncontrolled Keywords: Antibacterial activities,Berberis vulgaris asperma,Gram-negative bacteria
Subjects: QV pharmacology
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: zahra bagheri .
Date Deposited: 06 Sep 2017 10:22
Last Modified: 11 Sep 2017 03:05
URI: http://eprints.skums.ac.ir/id/eprint/4697

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