Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function

Amidi, Nilofar. and Moradkhani, Shirin. and Sedaghat, Mahsa. and Khiripour, Nejat. and Larki-Harchegani, Amir. and Zadkhosh, Nahid. and Mirhoseini, Mahmoud. and Ranjbar, Akram. (2015) Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function. Journal of Herbmed Pharmacology, 5.

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Abstract

Introduction: Cisplatin is one of the most potent chemotherapeutic antitumor drugs. Also, oxidative stress has been established to be involved in cisplatin-induced toxicity. Therefore, the present study was undertaken to examine the antioxidant and anti-inflammation potential of green tea hydroalcoholic extract (GTE) against the liver function of cisplatin in male rats.Methods: Adult male Wistar rats (180–250 g) were divided into 4 groups (n = 5) treated as follows: (1) control group (saline solution, 1 ml kg−1 body weight, i.p.), cisplatin group (7 mg kg−1 body weight, i.p.). Animals of Groups III received only green tea extract (30 mg/kg/day, by gavage). Group IV was given green tea extract+ cisplatin once daily for 24 hours. Liver function was evidenced in the cisplatin group by the increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The mechanism of cisplatin induced liver function was considered as being decreased the total antioxidant power (TAP). Systemic inflammation was assessed by tumor necrosis factor-alpha (TNF-α) levels.Results: A decrease in TAP level in cisplatin group was observed compared with control group. GTE administration decreased TNF-α and increased TAP compared to cisplatin group, but showed no significant differences between groups.Conclusion: The results suggested that green tea could ameliorate cisplatin liver function in rats through reduction of oxidative toxic stress and inflammation.

Item Type: Article
Uncontrolled Keywords: Cisplatin Green tea Inflammation Liver function Oxidative toxic stress
Subjects: WK Endocrine System
QU Biochemistry
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: Users 1 not found.
Date Deposited: 10 Sep 2017 03:47
Last Modified: 07 Mar 2018 06:25
URI: http://eprints.skums.ac.ir/id/eprint/4693

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