Preliminary assessment of the antiproliferative potential of Ananas comosus (pineapple) fruit juice

Chinedu, E. and Arome, D. and Jacob, D. (2016) Preliminary assessment of the antiproliferative potential of Ananas comosus (pineapple) fruit juice. Journal of Herbmed Pharmacology, 5.

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Abstract

Introduction: Cancer is a complex genetic ailment and a significant public health disease. Reports have shown that about 30–40 of all cancers can be prevented by lifestyle and dietary procedures alone. This study was aimed to evaluate the anti-proliferative effect of Ananas comosus fruit juice on rapidly proliferating cells.Methods: The study was carried-out on rapidly proliferating seeds of Sorghum bicolor. Five groups consisting of 20 seeds each were used. Groups 1-2 were the control and methotrexate groups respectively, while groups 3-5 were the test groups treated with different concentrations of A. comosus. The mean lengths (mm) of radicle emerging from the seeds were measured after 24, 48 and 72 hours.Result: The result showed that the control S. bicolor seeds radicle had a very high growth rate throughout the study. The methotrexate treated seeds showed a significant (P<0.05) retardation in growth of radicle length when compared with control, after 48 and 72 hours. The inhibition rate was 73.93 and 88.45. All doses (40-80 v/v) of A. comosus fruit juice showed a remarkable inhibition of seeds radicle growth, after 48 and 72 hours. The percent inhibition after 48 and 72 hours for 40 v/v was 72.39 and 84.36, for 60 v/v was 53.22 and 72.58, while that of 80 v/v was 87.35 and 94.78, respectively. The percent inhibition at 80 v/v was also higher than that produced by methotrexate throughout the study.Conclusion: The findings from the study indicate that A. comosus fruit juice has an antiproliferative effect.

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