Chinedu, Enegide. and Arome, David. and Jacob, Dabum Luka. (2016) Preliminary assessment of the antiproliferative potential of Ananas comosus (pineapple) fruit juice. Journal of Herbmed Pharmacology, 5.
|
Text
1.pdf Download (523kB) | Preview |
Abstract
Introduction: Cancer is a complex genetic ailment and a significant public health disease. Reports have shown that about 30–40 of all cancers can be prevented by lifestyle and dietary procedures alone. This study was aimed to evaluate the anti-proliferative effect of Ananas comosus fruit juice on rapidly proliferating cells.Methods: The study was carried-out on rapidly proliferating seeds of Sorghum bicolor. Five groups consisting of 20 seeds each were used. Groups 1-2 were the control and methotrexate groups respectively, while groups 3-5 were the test groups treated with different concentrations of A. comosus. The mean lengths (mm) of radicle emerging from the seeds were measured after 24, 48 and 72 hours.Result: The result showed that the control S. bicolor seeds radicle had a very high growth rate throughout the study. The methotrexate treated seeds showed a significant (P<0.05) retardation in growth of radicle length when compared with control, after 48 and 72 hours. The inhibition rate was 73.93 and 88.45. All doses (40-80 v/v) of A. comosus fruit juice showed a remarkable inhibition of seeds radicle growth, after 48 and 72 hours. The percent inhibition after 48 and 72 hours for 40 v/v was 72.39 and 84.36, for 60 v/v was 53.22 and 72.58, while that of 80 v/v was 87.35 and 94.78, respectively. The percent inhibition at 80 v/v was also higher than that produced by methotrexate throughout the study.Conclusion: The findings from the study indicate that A. comosus fruit juice has an antiproliferative effect.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Ananas comosus Pineapple Antiproliferative potential |
Subjects: | WH Hemic and Lymphatic System QV pharmacology > QV 752 Pharmacognosy |
Divisions: | Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology |
Depositing User: | Users 1 not found. |
Date Deposited: | 10 Sep 2017 03:15 |
Last Modified: | 28 Feb 2018 05:48 |
URI: | http://eprints.skums.ac.ir/id/eprint/4685 |
Actions (login required)
![]() |
View Item |