Assessment of the protective effect of vitamin E on the quality of spermatogenesis and sperm parameters in rats exposed to lead

Dadkhah, N. and Shahnazi, M. and Mesgari Abbasi, M. and Etemadifar, Sh. (2016) Assessment of the protective effect of vitamin E on the quality of spermatogenesis and sperm parameters in rats exposed to lead. Advanced Herbal Medicine, 2 (2). pp. 6-14.

[img]
Preview
Text
34.pdf

Download (441kB) | Preview
Official URL: http://herbmed.skums.ac.ir/article_22282.html

Abstract

Background and aims: Vitamins are a rich source of antioxidants that can neutralize the harmful effects of lead on spermatogenesis and sperm parameters. The aim of this study was to determine the effects of vitamin E on spermatogenesis and sperm parameters in lead-exposed rats. Methods: This is an experimental study on 45 male Wistar that were allocated to 5 groups: distilled water gavage, intraperitoneal distilled water, vitamin E, lead, and lead+ vitamin E. All the rats were exposed to lead for 30 days. Then, the rats were sacrificed and sperm count, motility and morphology of sperm chromatin, and epididymitis and testis weight were investigated. Results: The findings showed significant differences in weight gain, epididymitis weight, sperm death, the highest mobility of sperm among the groups (P>0.05). Vitamin E and control (gavage) rats experienced more weight than other groups. There was a significant difference in the highest mobility of sperm between peritoneal control group and other groups (P<0.001), and in lower than 50 mobility between lead group and other groups (P>0.05). There was a significant difference in sperm death between lead group, and the control groups and vitamin E group (P>0.05) with the least sperm death. Vitamin E group had a significantly lower sperm death than other groups. There was no significant difference in the testis weight, normal morphology, and normal DNA among the groups (P<0.05). Vitamin E had noticeable effects on gaining weight, epididymitis weight, and survived sperm, and a noticeable reducing effect on lead's harmful side effects on the sperm. Conclusions: The results indicate the protective effects of vitamin E on spermatogenesis quality and some sperm parameters in rats exposed to lead.

Item Type: Article
Uncontrolled Keywords: Lead; VitaminE; Spermatogenesis
Subjects: WJ Urogenital System
QU Biochemistry > Nutrition.vitamins
Divisions: Reserach Vice-Chancellar Department > Advanced Herbal Medicine
Depositing User: zahra bagheri .
Date Deposited: 06 Sep 2017 06:24
Last Modified: 06 Sep 2017 06:24
URI: http://eprints.skums.ac.ir/id/eprint/4641

Actions (login required)

View Item View Item