Ameliorating the effect of Zingiber officinale (ginger) hydroethanolic extract on scopolamine-induced memory impairment in adult male rats

Hosseinipour, A. and Gomar, A. and Mirazi, N. and Gomar, M. (2015) Ameliorating the effect of Zingiber officinale (ginger) hydroethanolic extract on scopolamine-induced memory impairment in adult male rats. Advanced Herbal Medicine, 1 (4). pp. 35-42.

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Official URL: http://herbmed.skums.ac.ir/article_15882.html

Abstract

Background and aims: The spice Zingiber officinale or ginger possesses antioxidant and neuroprotective effects. In this study we hypothesized that treatment with hydroethanolic extract of ginger (50, 100 and 200 mg/kg, p.o) would have an effect on the scopolamine-induced memory impairment in rats. Methods: In this experimental study, 64 male Wistar rats were divided into eight groups (8 rats in each group): normal saline, scopolamine (1 mg/kg), ginger extract (50, 100 and 200 mg/kg), or scopolamine (1 mg/kg) plus ginger extract (50, 100 and 200 mg/kg). Memory impairment was induced with a single injection of scopolamine (1 mg/kg, i.p). Cognitive functions were evaluated using passive avoidance learning (PAL) task. Retention test was carried out 24 hours after training, and the latency of entering the dark compartment step-through latency (STL) and the total time in the dark compartment (TDC) were recorded. All statistical analysis was carried out at 5% level of significance using SPSS version 21. The data were analyzed by ANOVA followed by Tukey’s test. Results: The time latency in scopolamine-treated group was lower than control (p<0.001). Treatment of the animals by 100 and 200 mg/kg of ginger extract before the training trial increased the time latency at 24 h after the training trial (p<0.01). Also, administration of extract at doses of 100 and 200 mg/kg in scopolamine received groups before retention trials, increased the time latency than the scopolamine only treated groups (p<0.001). Conclusion: The results revealed that the ginger hydroethanolic extract attenuated scopolamine-induced memory impairment.

Item Type: Article
Uncontrolled Keywords: Memory; Alzheimer; Ginger; Scopolamine; Rat
Subjects: WL Nervous system
WM Psychiatry
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Advanced Herbal Medicine
Depositing User: zahra bagheri .
Date Deposited: 06 Sep 2017 05:35
Last Modified: 06 Sep 2017 05:35
URI: http://eprints.skums.ac.ir/id/eprint/4624

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