The effects of Urtica dioica extract on lipid profile, insulin resistance index and liver histology in polycystic ovary syndrome-induced Wistar rats

Zare, Samad. and Nabiuni, Mohammad. and Tayanloo, Akram. and Hoseini, Serwa. and Karimzadeh-Bardei, Latifeh. (2015) The effects of Urtica dioica extract on lipid profile, insulin resistance index and liver histology in polycystic ovary syndrome-induced Wistar rats. Advanced Herbal Medicine, 1 (2). pp. 23-33.

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Abstract

Background and aims: Urtica dioica as a medicinal herb due to its anti-inflammatory, antioxidant and hypoglycemic effects, improve type 2 diabetes and decrease inflammation, fibrosis and necrosis as the signs of Nonalcoholic steatohepatitis. Polycystic Ovary Syndrome (PCOS) as the most important factor of infertility has an overlap of 30 to 60 with liver disorders. Hence, the Urtica dioica moderator effect on liver function in PCOS rats was examined. Methods: In this experimental study 144 adult Wistar rats were divided into control, PCOS and nettle-treated groups. The group PCOS was injected subcutaneously 2 mg estradiol valerate, after 60 days and confirmed polycystic, the experimental group was injected intraperitoneally the Urtica dioica extract doses (150,250, 450 mg/kg BW). After 21 days, rats were anesthetized by chloroform; blood samples and livers were collected for histological and serological evaluation. Data were analyzed using instat3 via ANOVA one-way and p

Item Type: Article
Uncontrolled Keywords: Urtica dioica; Polycystic Ovary Syndrome; Liver; Necrosis; Insulin resistance
Subjects: WK Endocrine System
WP Gynecology
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Advanced Herbal Medicine
Depositing User: zahra bagheri .
Date Deposited: 06 Sep 2017 04:46
Last Modified: 28 Mar 2018 05:40
URI: http://eprints.skums.ac.ir/id/eprint/4610

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