Evaluation of serum concentration of AFP marker in toxoplasmosis pregnant women with high level of IgG & IgM toxoplasma antibody by ELISA assay in a population of Tehran,Iran

Sadraie, Javid and Shariat Bahadory, Ehsan. and Ghaffari Novin, Sekhavat. (2016) Evaluation of serum concentration of AFP marker in toxoplasmosis pregnant women with high level of IgG & IgM toxoplasma antibody by ELISA assay in a population of Tehran,Iran. International Journal of Epidemiologic Research, 3 (1). pp. 3-11.

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Abstract

Background and aims: Toxoplasmosis is a parasitic disease which may cause some laboratory symptoms in infected individuals. One of the main ways of transmition this organism is placenta to fetus pathway. If this transmission occurs in the 3th month of pregnancy, the abortion, central nerve system and ocular disorder will happen. Because of this issue, the precise technique for detection of Toxoplasma Antibody such as IgG and IgM is important, that contains ELISA to detect Toxoplasma Antibody such as IgG and IgM and AFP. Methods: This was a cross sectional study. In this study, the main sample was serum that was randomly collected from 255 pregnant women infected with toxoplasma Gondi in Avesina center. Then, It was detected the serum concentration of AFP in toxoplasmosis pregnant women with high level of IgG and IgM toxoplasma antibody by ELISA assay. Results: The results of this survey showed that the infection in these pregnant women by toxoplasma gondii was occurred and 13 of them (13 of 255 infected mothers) had high levels of AFP in their serum. The statistical analyses was done by SPSS consisted of t-test, case number, comparative study, and Q-Q plot evaluations. Conclusions: In some pregnant women with high level of IgG and IgM toxoplasma antibody was observed in high levels of AFP in their serum and this index correlates with NTD in their fetus.

Item Type: Article
Uncontrolled Keywords: : Toxoplasma gondii, ELISA, IgG antibody, IgM antibody, AFP, IRAN.
Subjects: WC Communicable Diseases > Tropical and parasitic Diseases
WQ Obstetrics
QW Microbiology and Immunology
Divisions: Reserach Vice-Chancellar Department > International Journal of Epidemiologic Research
Depositing User: zahra bagheri .
Date Deposited: 05 Sep 2017 07:52
Last Modified: 19 May 2018 07:29
URI: http://eprints.skums.ac.ir/id/eprint/4530

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