Effects of antidepressants on morphine withdrawal

Rafieian-Kopaei, M. (1998) Effects of antidepressants on morphine withdrawal. Iranian Journal of Medical Sciences, 23 (3-4). pp. 120-125.

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The acute and chronic effects of paroxetine and fluoxetine on naloxone- withdrawal-induced place aversion in morphine dependent rats were investigated. Acutely administered fluoxetine (25 mg/kg, s.c., given 30 min prior to naloxone withdrawal pairing) and chronic daily paroxetine (10 mg/kg, s.c.) co-administration with a morphine induction protocol, both attenuated morphine withdrawal place aversion. Conversely, acutely administered paroxetine (up to 25 mg/kg, s.c.) or chronic daily fluoxetine (10 mg/kg, s.c.) co-administration with morphine did not modify subsequent withdrawal place aversion. Previous radioligand binding studies have indicated that fluoxetine has opioid-displacing properties. It is suggested therefore that acute fluoxetine may have decreased withdrawal aversion, probably through serotonin and also, in part, via an opioid-like mechanism whereas chronic paroxetine decreased withdrawal aversion by a serotonergic mechanism, but it is not clear whether opioid systems play any role in the action of paroxetine.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: antidepressant agent; fluoxetine; morphine; naloxone; paroxetine, animal cell; animal tissue; article; aversion; controlled study; depression; drug mechanism; male; morphine addiction; nonhuman; place preference; rat; serotonin release; withdrawal syndrome
Subjects: WM Psychiatry
QV pharmacology > QV 704 Pharmaceutics
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 21 Aug 2017 09:59
Last Modified: 21 Aug 2017 09:59
URI: http://eprints.skums.ac.ir/id/eprint/3486

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