In vitro study of relationship between signal intensity and gadolinium-DTPA concentration at high magnetic field strength

Shahbazi-Gahrouei, D. and Williams, M. and Allen, B. (2001) In vitro study of relationship between signal intensity and gadolinium-DTPA concentration at high magnetic field strength. Australasian Radiology, 45 (3). pp. 298-304.

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Abstract

Although gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) has been used as a contrast material in MRI, it is known that the contrast enhancement effect is not uniform for high concentrations of Gd-DTPA. In order to evaluate the proper pulse sequences for dynamic MRI in aqueous solutions of Gd-DTPA, blood samples and melanoma cells, the signal intensity for several concentrations of Gd-DTPA were measured under inversion recovery (T1weighted) at high magnetic field strength (7.0 Tesla). For aqueous solutions of Gd-DTPA, signal intensity correlated linearly with the concentration of Gd-DTPA between 0 mmol/L and 4 mmol/L Using blood and melanoma cells, signal intensity correlated non-linearly with the concentration of Gd-DTPA between 0 mmol/L and 1.5 mmol/L. For concentrations of more than 4 mmol/L in aqueous solutions of Gd-DTPA, 1 mmol/L in blood and 1.5 mmol/L in melanoma, signal intensity decreased with increased Gd-DTPA concentration.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: contrast medium; diagnostic agent; gadolinium pentetate; sodium chloride, article; blood; image enhancement; in vitro study; melanoma; methodology; nuclear magnetic resonance imaging; osmolarity; solution and solubility, Blood; Contrast Media; Gadolinium DTPA; Image Enhancement; Magnetic Resonance Imaging; Melanoma; Osmolar Concentration; Sodium Chloride; Solutions
Subjects: QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Medicine
Depositing User: Users 1 not found.
Date Deposited: 20 Aug 2017 06:26
Last Modified: 20 Aug 2017 06:26
URI: http://eprints.skums.ac.ir/id/eprint/3483

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