Synthesis and application of new gadolinium-porphyrins as potential MR imaging contrast agents for cancer detection in nude mice

Shahbazi-Gahrouei, D. and Williams, M. and Allen, B. (2001) Synthesis and application of new gadolinium-porphyrins as potential MR imaging contrast agents for cancer detection in nude mice. Iranian Biomedical Journal, 5 (2-3). XI-XII.

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Abstract

Two new potential magnetic resonance imaging contrast agents, Gd-hematoporphyrin (Gd-H) and Gd-tetra-carboranylmethoxyphenyl-porphyrin (Gd-TCP), were synthesized and applied to nude mice with human melanoma (MM-138) xenografts. These agents showed a high relaxivity because of their greater potential to coordinate water molecules. The reduction of T1 relaxation times of 16 and 21% was observed in human melanoma tumors grafted in the nude mice 24 h after injection of Gd-TCP andGd-H, respectively. The percent of injected Gd, that localized to the tumor and measured by inductively coupled plasma atomic emission spectroscopy (ICP-AES), was approximately 21% for Gd- TCP and 28% for Gd-H. A higher concentration of Gd was achieved compared with control indicating selective delivery of Gd-porphyrins to the melanoma xenografts. The data indicate that Gd-TCP can be used as a dual probe for diagnosis in MR imaging and for therapy in boron neutron capture therapy (BNCT).

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: MR imaging, Contrast agent, Porphyrins, Melanoma, Cancer
Subjects: WN Radiology . Diagnostic Imaging
Divisions: Faculty of Medicine
Depositing User: Users 1 not found.
Date Deposited: 20 Aug 2017 06:30
Last Modified: 20 Aug 2017 06:30
URI: http://eprints.skums.ac.ir/id/eprint/3482

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