The effect of quinapril on the aortic contractile response of streptozotocin-diabetic rats

Dehkordi, F. and Roghani, M. and Mojarad, T. (2003) The effect of quinapril on the aortic contractile response of streptozotocin-diabetic rats. Iranian Biomedical Journal, 7 (4). pp. 173-177.

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Abstract

Angiotensin-converting enzyme (ACE) inhibitors appear to correct many of the abnormalities associated with the vascular dysfunction found in diabetic patients. In this respect, quinapril is a unique ACE inhibitor with multiple protective effects. The present study was carried out to investigate the effect of intraperitoneal administration of quinapril on the aortic reactivity of streptozotocin (STZ)-diabetic rats. For this purpose, male Wistar rats received one injection of streptozotocin (STZ), 60 mg/kg, to induce diabetes. Three days after STZ injection, rats were treated with quinapril (2 mg/kg/day) for 4 weeks, after that aortic reactivity to vasoactive agents were compared with those of untreated diabetic rats or non-diabetic control rats. For this purpose, contractile response to phenylephrine (PE) was obtained from aortic rings. Concentration-response curves from quinapril-treated diabetic rats to PE in the presence and absence of endothelium were attenuated as compared to vehicle-treated diabetics. Therefore, the 4-week treatment of diabetic rats with quinapril could prevent the functional changes in vascular reactivity in diabetic rats.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: phenylephrine; quinapril; streptozocin; vasoactive agent, animal experiment; animal model; aorta; article; blood vessel reactivity; concentration response; controlled study; diabetes mellitus; drug effect; heart muscle contractility; male; nonhuman; rat; rat strain; streptozocin diabetes; vascular ring, Rattus norvegicus
Subjects: WD Nutrition Disease and metabolic diseases
WG Cardiovascular System
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Cardiology
Depositing User: zahra bagheri .
Date Deposited: 20 Aug 2017 06:43
Last Modified: 20 Aug 2017 06:43
URI: http://eprints.skums.ac.ir/id/eprint/3477

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