B-mode ultrasonography of carotid and femoral arteries for calcified plaques in chronic renal failure, hemodialysis and kidney transplant patients

Nasri, H. and Baradaran, A. (2004) B-mode ultrasonography of carotid and femoral arteries for calcified plaques in chronic renal failure, hemodialysis and kidney transplant patients. Hong Kong Journal of Nephrology, 6 (2). pp. 109-111.


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Objectives: To compare the presence of plaques in the carotid and femoral arteries of chronic renal failure (CRF) patients not yet on hemodialysis, or on maintenance hemodialysis, and kidney transplant patients with those of normal controls, and to consider the relationship of plaques to serum lipoprotein(a) Lp(a). Methods: There were 130 subjects divided into four groups: group 1 comprised 29 healthy controls; group 2 was made up of 33 CRF patients; group 3 of 43 hemodialysis patients; group 4 had 25 kidney transplant recipients. All patients underwent B-mode ultrasonography examination of the right and left carotid and femoral arteries for plaques; they were scored from 0 (no plaques) to 4 (plaques at all 4 sites). After a 14-hour overnight fast, blood samples from all patients were evaluated for blood urea nitrogen, creatinine, and serum lipids, including Lp(a). Results: A plaque score of zero was most common in group 1 (93%), followed by groups 4 (68%), 3 (51.2%), and 2 (39.4%). Plaque scores of 1-2 increased from group 1 (6.8%) through groups 2 (24.3%) and 3 (25.6%) to group 4 (32%). Plaque scores of 3-4 were lowest in groups 1 and 4 (0%) and highest in group 2 (36.4%); they were 23.3% in group 3. Serum Lp(a) in groups 1, 2, 3, and 4 were 42, 56, 55, and 54 mg/dL, respectively. There were significant differences in plaque scores (p < 0.001) and serum Lp(a) (p = 0.016) among the four groups. A significant positive correlation was found between plaque score and patient age in groups 2, 3, and 4. There was a significant correlation between plaque score and serum Lp(a) in group 3. Conclusion: Age is an important factor in the occurrence of arterial plaques in renal failure patients, before dialysis and on maintenance hemodialysis, and in kidney transplant patients. The positive association between serum Lp(a) and arterial plaques in hemodialysis patients may indicate that Lp(a) is a factor in the rapidly progressive atherosclerosis seen in hemodialysis patients.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: creatinine; lipid; lipoprotein A; urea, adult; age; aged; article; atherosclerotic plaque; B scan; carotid artery; chronic kidney failure; controlled study; correlation analysis; creatinine blood level; diet restriction; female; femoral artery; hemodialysis; human; kidney failure; kidney transplantation; lipid blood level; lipoprotein blood level; maintenance therapy; major clinical study; male; priority journal; scoring system; urea nitrogen blood level
Subjects: WG Cardiovascular System
WJ Urogenital System
WN Radiology . Diagnostic Imaging
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Depositing User: Users 1 not found.
Date Deposited: 21 Aug 2017 09:50
Last Modified: 21 Aug 2017 09:50
URI: http://eprints.skums.ac.ir/id/eprint/3465

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