Quinapril attenuates the effect of long-term L-NAME administration on the vascular reactivity of diabetic rats

Roghani Dehkordi, F. and Roghani, M. and Baluchnejadmojarad, T. (2005) Quinapril attenuates the effect of long-term L-NAME administration on the vascular reactivity of diabetic rats. Iranian Biomedical Journal, 9 (1). pp. 33-36.

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Abstract

Angiotensin-converting enzyme (ACE) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. The present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (STZ)-diabetic rats treated for 4 weeks with nitro-L-arginine- methyl ester (L-NAME; 50 mg/100 ml) or L-NAME plus quinapril (10 mg/100 ml) in drinking water. The results showed that quinapril treatment significantly attenuated the augmented contractile response to phenylephrine and KCl in diabetic rats. In addition, quinapril treatment partially restored the reduced contractile response in diabetic animals treated chronically with L-NAME. It can be concluded that quinapril could partly counteract the effect of long-term L-NAME administration on vascular reactivity in STZ-diabetic rats.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: dipeptidyl carboxypeptidase inhibitor; n(g) nitroarginine methyl ester; phenylephrine; potassium chloride; quinapril, animal experiment; animal model; animal tissue; article; blood vessel reactivity; chronic drug administration; controlled study; diabetes mellitus; heart protection; male; nonhuman; rat; streptozocin diabetes; vascular endothelium; vascular ring, Animalia
Subjects: WD Nutrition Disease and metabolic diseases
WG Cardiovascular System
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Cardiology
Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Depositing User: zahra bagheri .
Date Deposited: 21 Aug 2017 09:48
Last Modified: 21 Aug 2017 09:48
URI: http://eprints.skums.ac.ir/id/eprint/3463

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