Platelet count and mean volume (MPV) in association with plasma HCO 3 - in regular hemodialysis patients

Nasri, H. and Baradaran, A. (2006) Platelet count and mean volume (MPV) in association with plasma HCO 3 - in regular hemodialysis patients. Revista Brasileira de Hematologia e Hemoterapia, 28 (2). pp. 127-130.


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End-stage renal failure often is associated with abnormal bleeding that may represent an important complication of this disorder. The hemorrhagic tendency currently is attributed to altered primary hemostasis, mainly platelet dysfunction. The aim of the present study was to elucidate whether and how in patients, with uremia on hemodialysis, the level of plasma HCO3 - affects the mean PLT volume (MPV) and count. The total patients were 36 (f=15, m=21). The mean patients' age was 46 (±16) years. The mean length of the time patients had received hemodialysis was 32 (±36) months. The mean PLT count was 165 (±70) x103μ/L. The mean MPV was 9 (±1) fl. The mean plasma HCO3 - was 20 (±2.6) mEq/L. In this study a significant inverse correlation of PLT count with MPV and a significant positive association of PLT count with plasma HCO3 - and also a significant inverse correlation of MPV with plasma HCO3 - were found. Positive association of mild relative acidemia with PLT count and its negative correlation with MPV may further support the reverse epidemiology of serum bicarbonate in end-stage renal disease patients on hemodialysis which needs more attention as a protective role in mild relative acidosis of regular hemodialysis patients.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: Platelet count; hemodialysis; end-stage renal failure; mean platelet volume (MPV); plasma HCO3 - .
Subjects: WH Hemic and Lymphatic System
WJ Urogenital System
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Infectious Diseases
Depositing User: Users 1 not found.
Date Deposited: 21 Aug 2017 07:50
Last Modified: 21 Aug 2017 07:50

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