Impact of serum homocysteine on platelet count in stable hemodialysis patients

Nasri, H. (2006) Impact of serum homocysteine on platelet count in stable hemodialysis patients. Journal of Applied Research, 6 (1). pp. 14-18.


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Objective: The objective of this study was to elucidate whether and how the level of homocysteine as a cause of hemostatic abnormalities affects platelet count in hemodialysis patients with uremia. Methods: A cross-sectional study was conducted on patients with end-stage renal disease (ESRD) who were undergoing maintenance hemodialysis treatment with acetate basis dialysate and polysulfone membranes. Serum total homocysteine (HCY), hemoglobin, platelet (PLT), and white blood cell (WBC) counts were measured. Levels of serum calcium (Ca), phosphorus (P), and magnesium (Mg) were also measured. There were 39 study patients (15 female, 24 male) with a mean age of 46 ± 18 years. Results: The duration of dialysis treatment was 31 ± 35 months (median, 18 months).The value of serum homocysteine for all the patients was 5 ± 2.5 μmol/L (median, 4.5 μmol/L).The mean PLT count was 155 ± 77 × 103 u/L (median, 158 × 103 u/L). Conclusion: This study showed a significant positive correlation of PLT count with serum homocysteine (r=0.35, P=0.044). In hemodialysis patients high homocystiene levels make the platelets more likely to clump and cause clots and contribute to the possibility of thrombotic events among these patients.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: acetic acid; calcitriol; calcium carbonate; ferric hydroxide sucrose; folic acid; hemoglobin; homocysteine; iron; levacecarnine; polysulfone; recombinant erythropoietin; sevelamer, adult; anemia; article; calcium blood level; clinical article; dialysate; female; hemodialysis; human; hyperparathyroidism; kidney failure; leukocyte count; magnesium blood level; male; phosphate blood level; thrombocyte count; uremia
Subjects: WH Hemic and Lymphatic System
WJ Urogenital System
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Depositing User: zahra bagheri .
Date Deposited: 21 Aug 2017 07:47
Last Modified: 21 Aug 2017 07:47

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