Association of serum leptin with various biochemical parameters of bone turnover in maintenance hemodialysis patients

Nasri, H. (2006) Association of serum leptin with various biochemical parameters of bone turnover in maintenance hemodialysis patients. Pakistan Journal of Nutrition, 5 (2). pp. 180-184.

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Abstract

Leptin is a small peptide hormone that is mainly but not exclusively, produced in adipose tissue. leptin is cleared principally by the kidney. Serum leptin concentrations and bone mass are directly related. This cross-sectional study was conducted on patients with end-stage renal disease (ESRD), who were undergoing maintenance hemodialysis. Serum calcium, phosphorus, predialysis serum creatinine, blood urea nitrogen and also alkaline phosphatase (ALP) and also intact serum PTH (iPTH) and serum Leptin were measured too. In this study a significant difference of serum leptin between males and females of diabetic patients with more values in females was seen. In all patients a significant positive correlation of logarithm of serum leptin with logarithm of serum iPTH and a significant positive correlation of serum leptin and BMI in were found. In male hemodialysis patients a near significant and inverse correlation of serum ALP with serum leptin was seen, moreover in female hemodialysis patients a near significant inverse correlation of serum leptin with serum phosphorus and also a significant inverse correlation of serum leptin with CaXP products were found too. In hemodialysis patients serum leptin affects bone activity and need further investigation this aspect of hemodialysis patients. © Asian Network for Scientific Information, 2006.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: alkaline phosphatase; calcium; calcium carbonate; creatinine; leptin; nitrogen; parathyroid hormone; phosphorous acid; urea; vitamin D; phosphorus, adolescent; adult; alkaline phosphatase blood level; article; blood analysis; body mass; bone turnover; calcium blood level; clinical article; controlled study; correlation analysis; creatinine blood level; diabetes mellitus; enzyme linked immunosorbent assay; female; hemodialysis; human; kidney failure; maintenance therapy; male; parathyroid hormone blood level; protein blood level; radioimmunoassay; renal osteodystrophy; secondary hyperparathyroidism; sex difference; treatment duration; treatment outcome; urea blood level; urea nitrogen blood level; aged; biochemistry; cross-sectional study; kidney failure; phosphate blood level
Subjects: WH Hemic and Lymphatic System
WJ Urogenital System
QU Biochemistry
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Depositing User: zahra bagheri .
Date Deposited: 21 Aug 2017 07:33
Last Modified: 21 Aug 2017 07:33
URI: http://eprints.skums.ac.ir/id/eprint/3424

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