The association of serum leptin with biochemical parameters of bone turnover in maintenance hemodialysis patients

Nasri, H. and Baradaran, A. (2006) The association of serum leptin with biochemical parameters of bone turnover in maintenance hemodialysis patients. Archives of Hellenic Medicine, 23 (5). pp. 501-506.

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Abstract

OBJECTIVE: Leptin is a small peptide hormone that is mainly, but not exclusively, produced in adipose tissue and cleared principally by the kidney. Serum leptin concentrations and bone mass are directly related. This cross-sectional study was conducted on patients with end-stage renal disease (ESRD), who were undergoing maintenance hemodialysis (HD). METHOD: serum calcium, phosphorus, predialysis serum creatinine, blood urea nitrogen, alkaline phosphatase (ALP), intact serum PTH (iPTH) and serum leptin were measured in 36 dialysis patients, 10 of whom were diabetic. RESULTS: A significant difference in serum leptin between male and female diabetic patients was seen with higher values in females. In all patients a significant positive correlation of the logarithm of serum leptin with the logarithm of serum iPTH and a significant positive correlation of serum leptin with body mass index (BMI) were found, in male HD patients a near significant and inverse correlation of serum ALP with serum leptin was seen. In female HD patients a near significant inverse correlation of serum leptin with serum phosphorus and a significant inverse correlation of serum leptin with CaxP products were found. CONCLUSIONS: In HD patients serum leptin affects bone activity.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: alkaline phosphatase; calcium; creatinine; leptin; phosphorus, adult; aged; alkaline phosphatase blood level; article; body mass; bone turnover; calcium blood level; clinical article; creatinine blood level; diabetes mellitus; female; hemodialysis; hormone blood level; human; kidney failure; male; phosphate blood level; sex difference; urea nitrogen blood level
Subjects: WJ Urogenital System
QU Biochemistry
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Depositing User: zahra bagheri .
Date Deposited: 21 Aug 2017 07:22
Last Modified: 21 Aug 2017 07:22
URI: http://eprints.skums.ac.ir/id/eprint/3419

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