Strong inverse correlation between Helicobacter pylori infection and body mass index in male haemodialysis patients

Nasri, H. (2006) Strong inverse correlation between Helicobacter pylori infection and body mass index in male haemodialysis patients. Gastroenterologia Polska, 13 (6). pp. 437-440.

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Abstract

Introduction and Aim of study: In dialysis patients chronic infections induce overproduction of pro-inflammatory substances. Inflammation has been associated with cachexia and anorexia. Infection with H. pylori is also associated with anorexia, inflammation, and malnutrition in dialysis patients. This study aimed to evaluate the association of body mass index (BMI) of haemodialysis (HD) patients with Helicobacter pylori IgG antibodies to find the effects of H. pylori infection on the development of malnutrition. Material and methods: Patients with end-stage renal disease undergoing maintenance haemodialysis treatment who had had various upper gastrointestinal complaints consisting of epigastric pain, epigastric burning, postprandial fullness, early satiety, bloating and belching were studied. Serum Helicobacter pylori specific IgG antibody titers, serum Leptin, serum post and predialysis blood urea nitrogen, albumin, C-reactive protein were measured. Body mass index was calculated. Results: In this study no significant difference of serum H. pylori specific IgG antibody titer, serum Alb, serum leptin and BMI between males and females and also between diabetics and non diabetic HD patients were found. In all patients and in female non diabetic and diabetic groups no significant correlation of H. pylori IgG antibody titer with BMI was seen, while in male population a significant inverse correlation of H. pylori IgG antibody titer with BMI (r=0.54; P=0.009) (adjusted for age and urea reduction rate) was found. Conclusions: It is possible that inflammation and activity in antrum with H. pylori infection may be higher in men with end-stage renal disease on haemodialysis treatment, although this susceptibility needs more investigation with larger groups of patients. Copyright © 2006 Cornetis.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: albumin; C reactive protein; immunoglobulin G; leptin; nitrogen, adult; article; body mass; clinical article; controlled study; diabetes mellitus; epigastric burning; epigastric pain; female; gastrointestinal symptom; Helicobacter infection; Helicobacter pylori; hemodialysis; human; immunoglobulin blood level; kidney failure; male; malnutrition; postprandial state; satiety; urea nitrogen blood level
Subjects: WI Digestive System
WJ Urogenital System
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Depositing User: zahra bagheri .
Date Deposited: 21 Aug 2017 07:05
Last Modified: 21 Aug 2017 07:05
URI: http://eprints.skums.ac.ir/id/eprint/3413

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