Marjoram increases basal gastric acid and pepsin secretions in rat

Nabavizadeh Rafsanjani, Fatemeh. and Shahrani, Mehrdad. and Vahedian Ardakani, Zakieh. and Vahedian Ardakani, Mohammad. (2007) Marjoram increases basal gastric acid and pepsin secretions in rat. Phytotherapy Research, 21 (11). pp. 1036-1038.


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Considering the high consumption rate of marjoram in the Iranian population, this study was designed to investigate the effects of marjoram extract on gastric acid and pepsin secretion. In this study, Wistar rats (n = 12) were divided into two equal case and control groups. Under general anaesthesia with 50 mg/kg i.p. sodium thiopental, laparatomy was done and a cannula inserted in the duodenum. In the case animals marjoram (12.5 mg/kg) was injected into the stomach through the mentioned cannula. The gastric contents were collected by the wash-out technique. Acid and pepsin secretions were then measured by titration and the Anson method, respectively. In the marjoram group, basal acid and pepsin secretions were significantly increased compared with the control group (acid: 20 ± 3.36 vs 4.1 ± 0.36 μmol/15 min; pepsin: 9.04 ± 0.01 vs 5.62 ± 0.12 μg/15 min; p < 0.001). In the control group, pentagastrin stimulation increased acid secretion in comparison with the basal level (10.14 ± 1.34 vs 4.1 ± 0.36 μmol/15 min, p < 0.001), while in the marjoram group, there was a significant decline (16.46 ± 3.23 vs 20 ± 3.36 μnol/15 min, p < 0.001). In the marjoram group pentagastrin increased pepsin secretion in comparison with the basal state (12 ± 0.11 vs 9.04 ± 0.1 μ15 min, p < 0.001). It seems that marjoram contains some components that activate chief and parietal cells and increase basal acid and pepsin secretion. Copyright © 2007 John Wiley & Sons, Ltd.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: Origanum majorana extract; pentagastrin; pepsin A, animal experiment; article; controlled study; drug effect; drug mechanism; laparotomy; marjoram; medicinal plant; nonhuman; oregano; Origanum majorana; pepsin secretion; rat; stomach acid, Animals; Gastric Acid; Origanum; Pentagastrin; Pepsin A; Plant Extracts; Rats; Rats, Wistar; Stomach, Animalia; Rattus; Rattus norvegicus
Subjects: WI Digestive System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine
Depositing User: zahra bagheri .
Date Deposited: 21 Aug 2017 05:54
Last Modified: 07 May 2018 08:00

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