Diversity and relationship between Iranian ethnic groups: Human dopamine transporter gene (DAT1) VNTR genotyping

Banoei, Mohammad Mehdi. and Hashemzadeh-Chaleshtori, Morteza. and Sanati, Mohammad Hossein. and Shafa Sharait Panahi, Mehdi. and Majidizadeh, TAYEBEH. and Rostami, Maryam. and DEHGHAN Manshadi, Massoumeh. and Golalipour, Masoud. (2007) Diversity and relationship between Iranian ethnic groups: Human dopamine transporter gene (DAT1) VNTR genotyping. American Journal of Human Biology, 19 (6). pp. 821-826.


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The 40-bp VNTR polymorphism in the 3′ untranslated region of the human DAT1 (dopamine transporter 1) was analyzed in the Iranian ethnic groups in order to examine the influence of geographical and linguistic affiliation on the genetic affinities among the Iranian population. A total of 449 subjects belonging to nine ethnic groups from the Iranian population were included in the study. The screening of 898 chromosomes showed five alleles (6, 7, 8, 9, 10, and 11), of which allele 10 revealed the highest frequency in most regions. Allele 8 was predominant in one ethnicity and occurred more frequently in the center of Iran. This study shows that the DAT1 distribution in Iran has a different pattern from those in other studies, which can contribute to an understanding of differentiation and diversity of Iranian ethnic groups. This polymorphism could represent the genetic diversity among the various ethnic groups of Iran. © 2007 Wiley-Liss, Inc.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: dopamine transporter, 3' untranslated region; adult; article; Asian; chromosome analysis; controlled study; ethnic difference; ethnic group; gene frequency; gene identification; gene locus; genetic association; genetic difference; genetic polymorphism; genetic variability; genotype; geographic origin; human; Iran; linguistics; population research; priority journal; variable number of tandem repeat, Demography; Dopamine Plasma Membrane Transport Proteins; Ethnic Groups; Gene Frequency; Genotype; Geography; Humans; Iran; Minisatellite Repeats; Polymorphism, Genetic; Sampling Studies; Variation (Genetics)
Subjects: W General medicine- Health professions > W.20.55 H9 special topics A-Z (Human expenmentation)
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zahra bagheri .
Date Deposited: 21 Aug 2017 05:44
Last Modified: 19 May 2018 07:06
URI: http://eprints.skums.ac.ir/id/eprint/3394

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