Effect of Allium sativum L. extract on acid and pepsin secretion in basal condition and stimulated with vag stimulate in rat

Shahrani, M. and Rafieian, M. and Shirzad, H. and Hashemzadeh, M. and Yousefi, H. and Khadivi, R. and Amini, S.A. and Dehghan, M. and Khayri, S. and Moradi, M. and Rahimian, G. and Gheitasi, I. (2007) Effect of Allium sativum L. extract on acid and pepsin secretion in basal condition and stimulated with vag stimulate in rat. Journal of Medicinal Plants, 6 (24). pp. 28-37.

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Abstract

Background: Garlic is used world wide to give flavor to foods as pecols ect. by different nations specially by Iranian society. The dominant believe is, the garlic therapeutic effects on patients with gastric discomfort and digesting problems. Objective: in this study we aimed to investigate the garlic effect on gastric acid and pepsin in both basic and stimulated condition by electrical stimulus of voguesnerve in rat. Methods: in an experimental study two groups of 12 wistar rats were selected. to make the animal unconscious, 50mg/kg Sodium Tiopantal were given ip. and each rat was tracheostomized, laparatomized, gastrodeodonostomized and then 100 mg/kg of garlic extract dissolved in 9 saline was introduced to stomach of animal. The vagus nerves of both side of the neck released from carotid sheet and stimulated with 15millivolts, frequency 4 Herts and 1 milisecond wide. The stomach secretions then washed out in following stages; first base, second base, vagus stimulated conditions and reverse to base. The acid amounts of washing were measured by titrometry and pepsin amounts were measured with Anson technique. Results: the acid and pepsin secretion were significantly increased in rats received garlic extracts (p<0.000 p<0.05 respectively). Stimulation by vagus nerves in control group significantly increased the level of acid (p<0.05) and pepsin (p<0.05) and garlic treated group had similar secretion rate to stimulated group. Furthermore there were no significant relationship between sex of studied rats. Conclusion: consumption of garlic in the diet has lots of benefits for digestion of foods, so it can be beneficial for those patients with digestive problems, however it should be noted that people with digestive dysfunction related to increased level of gastric acid or pepsin must avoid garlic consumption. Therefore patient with gastritis and duodenal ulcer are not allowed to take garlic in their diet.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: acid; garlic extract; pepsin A; thiopental, animal experiment; animal tissue; article; controlled study; drug effect; drug solubility; duodenum ulcer; electrostimulation; female; garlic; gastritis; gastroduodenostomy; laparotomy; male; nonhuman; rat; stomach acid secretion; vagus nerve stimulation; Wistar rat, Allium sativum; Animalia; Rattus; Rattus norvegicus
Subjects: WI Digestive System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Health
Faculty of Health > Department of Epidemiology
Faculty of Medicine > Basic Sciences Academic Groups > Department of Biochemistry and Genetics
Faculty of Medicine > Basic Sciences Academic Groups > Department of Immunology
Faculty of Medicine > Basic Sciences Academic Groups > Department of Parasitology and Mycology
Faculty of Medicine > Basic Sciences Academic Groups > Department of Physiology
Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Faculty of Medicine > Department of Clinical Sciences > Department of Orthopedics
Faculty of Medicine > Department of Clinical Sciences > Department of pharmacology
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 21 Aug 2017 05:33
Last Modified: 21 Aug 2017 05:33
URI: http://eprints.skums.ac.ir/id/eprint/3391

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