Variation of DAT1 VNTR alleles and genotypes among old ethnic groups in Mesopotamia to the Oxus region

Banoei, M.M. and Hashemzade Chaleshtori, M. and Sanati, M.H. and Shariati, P. and Houshmand, M. and Majidizadeh, T. and Jahangir Soltani, N. and Golalipour, M. (2008) Variation of DAT1 VNTR alleles and genotypes among old ethnic groups in Mesopotamia to the Oxus region. Human Biology, 80 (1). pp. 73-81.

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Abstract

Variation of a VNTR in the DAT1 gene in seven ethnic groups of the Middle East was used to infer the history and affinities of these groups. The populations consisted of Assyrian, Jewish, Zoroastrian, Armenian, Turkmen, and Arab peoples of Iran, Iraq, and Kuwait. Three hundred forty subjects from these seven ethnic groups were screened for DAT1. DAT1 VNTR genotyping showed 3, 6, 7, 8, 9, 10, 11, and 12 alleles in the samples. Analysis of these data revealed differentiation and relationship among the populations. In this region, which covers an area of 2-2.5 million km2, the influence of geography and especially of linguistic characteristics has had potentially major effects on differentiation. Religion also has played a major role in imposing restrictions on some ethnic groups, who as a consequence have maintained their community. Overall, these ethnic groups showed greater heterogeneity compared to other populations. Copyright © 2008 Wayne State University Press.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: allele; Arab; article; controlled study; DAT1 gene; ethnic group; gene frequency; genetic heterogeneity; genetic variability; genotype; geographic distribution; human; human experiment; Iran; Iraq; jew; Kuwait; linguistics; Middle East; normal human; regulator gene; religion; variable number of tandem repeat, Dopamine Plasma Membrane Transport Proteins; Ethnic Groups; Genetics, Population; Humans; Middle East; Minisatellite Repeats; Variation (Genetics), Oxus
Subjects: W General medicine- Health professions > W.20.55 H9 special topics A-Z (Human expenmentation)
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zahra bagheri .
Date Deposited: 21 Aug 2017 05:18
Last Modified: 21 Aug 2017 05:18
URI: http://eprints.skums.ac.ir/id/eprint/3384

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