The effect of intramuscular midazolam on postoperative pain resulting from herniorraphy

Akhlaghi, Mahmood. and Rajaei, Mohammad. (2008) The effect of intramuscular midazolam on postoperative pain resulting from herniorraphy. Journal of Medical Sciences, 8 (3). pp. 302-305.


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The main purpose of this study was to assess the effect of intramuscular midazolam on postoperative pain and to test our hypothesis that the patients are more comfortable and suffering less pain after operation. Eighty male patients with ASA class (I, II), aged 15-60 years whom were scheduled for elective inguinal herniorraphy, were enrolled in this study in a double blind fashion. Patients were randomly assigned to two groups of forty, whom were randomly allocated for this study. Group A the test group received 0.1 mg kg-1 midazolam and group B the control group received 0.02 cc kg-1 saline, intramuscularly, just after inducing anesthesia with fentanyl 3 μg kg-1, thiopental 5 mg kg-1 as well as atracurium 0.5 mg kg-1. Popular McGill questionnaires were filled for pain severity assessment in four stages (1, 2, 3 and 8 h after operation) and the patients' vital signs were charted in five stages (preoperative and 1, 2, 3 and 8 h after operation). The data so obtained was analyzed statistically using Student t-test and Chi-square. First hour after operation, pain score average in group A was 2.3 in comparison with 6.6 in group B (p<0.05). After second and 3rd h of operation scores of 3.6 and 3.8 in comparison with 6.4 and 6.2 were related to group A and group B, respectively (p<0.05). Vital signs of the patients in group A were more stable than group B during the first hour of recovery period (p<0.05). Moreover, the need of intravenous opiate for relieving pain during recovery period in group A was less than group B (p<0.05). Intramuscular midazolam just after inducing anesthesia appears to cause pain relief after herniorraphy, particularly during early recovery period.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: atracurium; diazepam; fentanyl; midazolam; opiate; thiopental, adolescent; adult; analgesia; analgesic activity; article; breathing rate; disease severity; drug efficacy; general anesthesia; herniorrhaphy; human; major clinical study; male; operation duration; postoperative pain; postoperative period; pulse rate; questionnaire; systolic blood pressure; vital sign
Subjects: WO Surgery
QV pharmacology > QV 704 Pharmaceutics
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Anesthesiology
Faculty of Medicine > Department of Clinical Sciences > Department of Surgery
Depositing User: Users 1 not found.
Date Deposited: 21 Aug 2017 04:38
Last Modified: 19 Feb 2018 06:42

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