Incidence of acute peripheral neurotoxicity after deep regional hyperthermia of the pelvis

Wielheesen, D.H.M. and Sillevis Smitt, P.A.E. and Haveman, J. and Fatehi, Daryoush. and Van Rhoon, Gerard.C. and Van Der Zee, J. (2008) Incidence of acute peripheral neurotoxicity after deep regional hyperthermia of the pelvis. International Journal of Hyperthermia, 24 (4). pp. 367-375.

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Background: After observing rather severe acute neurotoxicity in a few patients following deep hyperthermia treatment for a pelvic tumour, we evaluated the incidence of neurotoxicity in all patients treated with deep hyperthermia of the pelvis between June 1990 and April 2004. Materials and methods: Hyperthermia treatment registrations and hospital charts of all 736 patients were reviewed. Differences between the incidence of neurotoxicity in subgroups of patients were evaluated by 2×2 exact tests. Results: Grade 2 or 3 acute neurotoxicity occurred in 2.3 of patients, grade 3 in 0.7. The duration of symptoms was longer than 3 months in 6 patients (0.8). Neurological examination in 5 patients showed that the most commonly involved structures are the sacral and lower lumbar nerve roots and the sacral plexus. Acute neurotoxicity occurred only after November 1999 and only in patients treated for primary cervical cancer. Comparison of applied powers and achieved temperatures in patients developing neurotoxicity did not show differences between treatment sessions which resulted in neurotoxicity and sessions not resulting in neurotoxicity. Conclusion: Acute neurotoxicity following hyperthermia for pelvic tumours is a rare complication, but can result in symptoms affecting the activities of daily life. We found no patient, tumour or treatment characteristics predictive for a risk of neurotoxicity.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: capecitabine; cisplatin, article; bladder cancer; disease severity; female; human; hyperthermic therapy; incidence; lumbar spine; lumbosacral plexus; major clinical study; male; neurologic examination; pelvis cancer; peripheral neuropathy; profound induced hypothermia; rectum cancer; spinal root; uterine cervix cancer, Female; Humans; Hyperthermia, Induced; Incidence; Male; Pelvis; Peripheral Nervous System
Subjects: WE Musculoskeletal system
WL Nervous system
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Radiology
Depositing User: zahra bagheri .
Date Deposited: 21 Aug 2017 04:26
Last Modified: 08 May 2018 06:17

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