I405V and -629C/A polymorphisms of the cholesteryl ester transfer protein gene in patients with coronary artery disease

Ghatreh Samani, Keihan. and Noori, Mohammad. and Rohbani Nobar, Mohammad. and Hashemzadeh-Chaleshtori, Morteza. and Farrokhi, Effat. and Darabi Amin, Masoud. (2009) I405V and -629C/A polymorphisms of the cholesteryl ester transfer protein gene in patients with coronary artery disease. Iranian Biomedical Journal, 13 (2). pp. 103-108.


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Background: Cholesteryl ester transfer protein (CETP) plays a main role in high-density lipoprotein metabolism. CETP gene possesses several single nucleotide polymorphisms which have been associated with plasma high-density lipoprotein cholesterol (HDL-C) concentrations. The aim of this study was to determine the association of CETP -629C/A and I405V polymorphisms with coronary artery disease (CAD) in Iranian population. Methods: The presence of two CETP gene polymorphisms -629C/A and I405V were studied in 187 unrelated CAD cases and 136 controls. All the samples were clinically examined and lipid profile was estimated. Genotyping was performed using polymerase chain reaction/restriction fragment length polymorphism method. Results: The frequency of -629C/A and I405V allelic variants were found to be 0.732 and 0.366 in cases and 0.658 and 0.348 in controls, respectively. The frequency of A allele of -629C/A polymorphism in cases was significantly higher than that of controls. HDL-C in AA genotype was higher than CA and CC genotypes in controls. No significant effect of II, IV and VV genotypes was found in lipid profiles. Conclusion: No significant association was found between CETP I405V polymorphism and increased risk of CAD in Azeri population studied. AA genotype of -629C/A increased HDL but the risk of CAD in this genotype might be higher than CC genotype.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: cholesterol ester transfer protein; lipid, adult; article; controlled study; coronary artery disease; disease association; DNA polymorphism; female; gene frequency; genetic risk; genotype; human; lipid blood level; major clinical study; male; polymerase chain reaction; restriction fragment length polymorphism, Amino Acid Substitution; Anthropometry; Cholesterol Ester Transfer Proteins; Coronary Artery Disease; Gene Frequency; Genotype; Humans; Isoleucine; Middle Aged; Polymorphism, Single Nucleotide; Valine
Subjects: WG Cardiovascular System
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zahra bagheri .
Date Deposited: 21 Aug 2017 03:34
Last Modified: 24 Feb 2018 07:04
URI: http://eprints.skums.ac.ir/id/eprint/3354

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