Chromosomal aberrations induced by a low dose of neutron irradiation and hyperthermia

Fatehi, D. (2009) Chromosomal aberrations induced by a low dose of neutron irradiation and hyperthermia. International Journal of Low Radiation, 6 (4). pp. 283-293.

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The purpose of this study was to investigate the effect of Hyperthermia (HT) on the Frequency of Chromosomal Aberrations (FCA) induced by a low dose of neutron irradiation. Blood samples were exposed to HT, 6cGy neutrons, HT + neutrons and neutrons + HT, and the FCA was scored in metaphase. HT alone at 41.5°C had no effect on FCA; however, the FCA was significantly higher at 43°C (p < 0.05). The FCA was significantly different when cells were irradiated with neutrons alone (p < 0.01). HT after neutron irradiation significantly affected the FCA (p < 0.05) and the FCA was markedly higher when cells were heated at 43°C. As cell death is directly related to the FCA, using HT after neutron irradiation may cause more cell deaths in human lymphocytes. The effect of HT on the FCA is most probably because of its inhibitory role in cell damage repair. Heating cells after neutron irradiation could be considered a suitable cancer treatment modality. Copyright © 2009 Inderscience Enterprises Ltd.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: adult; article; blood sampling; cell death; cell regeneration; chromosome aberration; controlled study; human; human cell; hyperthermic therapy; low energy radiation; lymphocyte; metaphase; neutron radiation; radiation dose; temperature measurement
Subjects: QZ pathology-Neoplasms
QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Medical Physics
Depositing User: zahra bagheri .
Date Deposited: 20 Aug 2017 10:07
Last Modified: 20 Aug 2017 10:07

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