The number of cytomegalovirus-specific CD4+ T cells is markedly expanded in patients with B-cell chronic lymphocytic leukemia and determines the total CD4+ T-cell repertoire

Pourgheysari, B. and Bruton, R. and Parry, H. and Billingham, L. and Fegan, C. and Murray, J. and Moss, P. (2010) The number of cytomegalovirus-specific CD4+ T cells is markedly expanded in patients with B-cell chronic lymphocytic leukemia and determines the total CD4+ T-cell repertoire. Blood, 116 (16). pp. 2968-2974.

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Abstract

B-cell chronic lymphocytic leukemia is associated with immune suppression and an altered T-cell repertoire with expansion of memory cells. Cytomegalovirus (CMV) is a common herpes virus that elicits a strong virus-specific T-cell immune response after infection. We studied the CMV-specific CD4+ T-cell response in 45 patients and 35 control subjects and demonstrated that it was markedly expanded in the patient group, averaging 11 of the CD4+ pool compared with 4.7 in controls. The magnitude of the CMV-specific CD4 + immune response increased with disease stage and was particularly high in patients who received chemotherapy.Within this group, the CMV-specific response comprised over 46 of the CD4+ T-cell repertoire in some patients. Serial analysis revealed that CMV-specific immunity increased during treatment with chemotherapy and remained stable thereafter. CMV-seropositive patients exhibited a markedly altered CD4+ T-cell repertoire with increased numbers of CD45R0+ T cells and a reduction in CD27, CD28, and CCR7 expression. Overall survival was reduced by nearly 4 years in CMV-seropositive patients, although this did not reach statistical significance. CLL patients therefore demonstrate an expansion of the CD4+ CMV-specific immune response, which is likely to contribute to the immunological and clinical features of this disease. © 2010 by The American Society of Hematology.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: CD27 antigen; CD28 antigen; CD45RO antigen; chemokine receptor CCR7; chlorambucil; fludarabine, adult; aged; article; B cell leukemia; cancer chemotherapy; cancer staging; cancer survival; CD3+ T lymphocyte; CD4+ T lymphocyte; cell count; cell expansion; cell specificity; chronic lymphatic leukemia; controlled study; Cytomegalovirus; female; human; immune response; major clinical study; male; priority journal; protein expression, Aged; Aged, 80 and over; Antigens, CD3; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Count; Cytomegalovirus; Cytomegalovirus Infections; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged
Subjects: WH Hemic and Lymphatic System
QU Biochemistry
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Pathology
Faculty of Medicine > Department of Clinical Sciences > department of hematology and ancology
Depositing User: zahra bagheri .
Date Deposited: 20 Aug 2017 08:22
Last Modified: 20 Aug 2017 08:22
URI: http://eprints.skums.ac.ir/id/eprint/3313

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