The effects of cornelian cherry on atherosclerosis and atherogenic factors in hypercholesterolemic rabbits

Rafieian-Kopaei, Mahmoud. and Asgary, Sedigheh. and Adelnia, Azadeh. and Setorki, Mahbubeh. and Khazaei, Majid. and Kazemi, Somayeh. and Shamsi, Fatemeh. (2011) The effects of cornelian cherry on atherosclerosis and atherogenic factors in hypercholesterolemic rabbits. Journal of Medicinal Plants Research, 5 (13). pp. 2670-2676.

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Abstract

Atherosclerosis results from gradual deposition of lipids in medium and large arteries and is the leading cause of death world wide. Due to the side effects of chemical compounds more attention has been paid to herbal remedies. This study was aimed to evaluate the curative effects of Cornus mas on atherosclerosis and its risk factors in hypercholesterolemic rabbits. Twenty five male New-Zealand rabbits weighing 2 to 2.5 kg were randomly desigrated into five groups of five and were fed for 60 days using the following diet regimens: Standard diet, standard diet plus C. mas (1 g/kg bw, daily), hypercholesterol diet (1), hypercholesterol diet plus C. mas (1 g/kg bw, daily), hypercholesterol diet plus lovastatin (10 mg/kg bw, Daily). The concentration of total cholesterol (TC), LDL cholesterol, triglycerides (TG) HDL cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), antioxidant capacity, malondialdehyde (MDA) and fibrinogen were determined in rabbits in the beginning and at the end of the experiment. Fatty streak formation was also evaluated. C. mas powder significantly increased antioxidant capacity and decreased MDA, fibrinogen and AIP (AIP = log TG/HDL) in plasma. It also decreased TC, LDL and TG levels and atherosclerotic lesion in the aorta, although the reduction was not statisticant. Results showed that consumption of C. mas might be beneficial in hypercholesterolemic patients due to its antioxidant and anti-inflammatory properties. © 2011 Academic Journals.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: alanine aminotransferase; antioxidant; aspartate aminotransferase; Cornus mas extract; fibrinogen; glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; malonaldehyde; plant extract; triacylglycerol; unclassified drug, animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; article; atherogenic diet; atherosclerosis; atherosclerotic plaque; cherry; cholesterol blood level; concentration (parameters); controlled study; Cornus; Cornus mas; diet supplementation; drug determination; experimental rabbit; glucose blood level; hypercholesterolemia; male; nonhuman; powder; risk factor, Cornus mas; Oryctolagus cuniculus
Subjects: WG Cardiovascular System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of pharmacology
Depositing User: zahra bagheri .
Date Deposited: 20 Aug 2017 06:48
Last Modified: 02 Jun 2018 04:14
URI: http://eprints.skums.ac.ir/id/eprint/3282

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