Effects of cornus mas L. on blood glucose, insulin and histopathology of pancreas in alloxan-induced diabetic rats

Shamsi, Fatemeh. and Asgari, Sedigheh. and Rafieian-Kopaei, Mahmoud. and Kazemi, Somayeh. and Adelnia, Azadeh. (2011) Effects of cornus mas L. on blood glucose, insulin and histopathology of pancreas in alloxan-induced diabetic rats. Journal of Isfahan Medical School, 29 (147). pp. 929-938.


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Background: Diabetes is a chronic disease characterized by elevated blood glucose levels and disturbances in carbohydrate, fat and protein metabolism. Cornus mas (cornaceae) is one of the major medicinal plants in Asian countries that cotained high level of anthocyanins with potential to prevent hyperglycemia and obesity. In this study, we investigated antidiabetic effects of cornus mas in compared to glibenclamid as a standard drug on alloxan-induced diabetic rats. Methods: Thirty two male Wistar rats (190-240 g) were divided into four groups (n = 8): group 1 nondiabetic rats, group 2 alloxan-induced diabetic rats with no treatment, group 3 alloxan-induced diabetic rats treated with glibenclamid (0.6 mg/kg body weight) and group 4 alloxan-induced diabetic rats treated with cornus mas fruit 2 g daily for 4 weeks. Diabetes was induced by single intraperitoneal injection of alloxan 120 (mg/kg body weight). Findings: The results indicated that treatment with cornus mas fruit orally significantly reduced blood glucose levels and increased insulin levels in treatment of diabetic rats compared with no treatment diabetic group. Concurrent histological studies of the pancreas demonstrated the same results. On the base of histological results, cornus mas have a significant on increasing the size of pancreatic islets than diabetic groups (P < 0.05). Conclusion: Our results showed that cornus mas fruit has antidiabetic effects and can improve pancreas damage caused by free radicals in diabetes. The effects of this fruit can occur due to the presence of anthocyanin and other antioxidant compounds.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: antidiabetic agent; glibenclamide; glucose; herbaceous agent; insulin, alloxan diabetes mellitus; animal experiment; animal model; animal tissue; article; controlled study; Cornus; Cornus mas; drug effect; drug efficacy; fruit; glucose blood level; histopathology; male; nonhuman; pancreas injury; pancreas islet; rat; treatment outcome; Wistar rat
Subjects: WD Nutrition Disease and metabolic diseases
WI Digestive System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 20 Aug 2017 06:13
Last Modified: 25 Feb 2018 08:51
URI: http://eprints.skums.ac.ir/id/eprint/3274

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