Weekly systemic cisplatin plus locoregional hyperthermia: An effective treatment for patients with recurrent cervical carcinoma in a previously irradiated area

Franckena, M. and De Wit, R. and Ansink, A.C. and Notenboom, A. and Canters, R.A.M. and Fatehi, D. and Van Rhoon, G.C. and Van Der Zee, J. (2007) Weekly systemic cisplatin plus locoregional hyperthermia: An effective treatment for patients with recurrent cervical carcinoma in a previously irradiated area. INTERNATIONAL JOURNAL OF HYPERTHERMIA, 23 (5). pp. 443-450.

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Abstract

Purpose: Patients with recurrent cervical carcinoma within a previously irradiated area respond poorly to chemotherapy. We have treated these patients with simultaneous cisplatin and hyperthermia ( CDDP+HT) and investigated response, toxicity, palliative effect and survival. Materials and methods: Between 1992 and 2005 47 patients received CDDP+HT. Response was evaluated by gynaecologic examination and CT-scan. The Common Toxicity Criteria ( CTC) were used for evaluation of toxicity and palliative effect. The Kaplan-Meier method was used to estimate survival, and Cox regression analysis to evaluate the influence of prognostic factors. Results: The objective response rate was 55%, palliation was achieved in 74% and operability in 19% of patients. Two patients are currently disease free at 9 years and 18+months following treatment and 2 remained disease free until death by other causes. The median survival was 8 months and was influenced by duration of disease free interval and tumour diameter. Grade 3-4 haematological toxicity was observed in 36% of patients and renal toxicity was maximum grade 2. Conclusion: CDDP+HT results in a high response rate and acceptable toxicity in patients with recurrent cervical cancer.

Item Type: Article
Uncontrolled Keywords: recurrent cervical carcinoma; cisplatin; hyperthermia
Subjects: WP Gynecology
QZ pathology-Neoplasms
Divisions: Faculty of Health > Department of Epidemiology
Faculty of Medicine > Department of Clinical Sciences > Department of Obstetrics and Gynecology
Faculty of Medicine > Department of Clinical Sciences > Department of Radiology
Faculty of Medicine > Department of Clinical Sciences > department of hematology and ancology
Depositing User: zahra bagheri .
Date Deposited: 20 Aug 2017 03:11
Last Modified: 20 Aug 2017 03:11
URI: http://eprints.skums.ac.ir/id/eprint/3172

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