The association between serum leptin and blood lymphocytes in hemodialysis patients

Nasri, H. (2007) The association between serum leptin and blood lymphocytes in hemodialysis patients. BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, 108 (3). pp. 122-127.

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Abstract

Aims: To find the association between serum leptin, blood lymphocytes and PMN percentages as markers of immune-system function, as well as nutritional status in long term hemodialysis patients. Patients and methods: In a group of long term hemodialysis patients, serum leptin, albumin, creatinine, BUN, and white-blood cell (WBC) count - lymphocytes and polymorphonuclear (PMN) cells] were measured. Results: A significant positive correlation between serum leptin and body-mass index and between serum leptin and lymphocyte percentage was found, as well as a significant negative correlation between serum leptin and PMN percentage. There was a weak negative correlation between WBC counts and the duration and dosage of dialysis, and also a near significant negative correlation between WBC counts and hemodialysis adequacy. There was also a significant negative correlation between WBC counts and serum albumin. Conclusion: Generally increased neutrophil coun and increased lymphocyte count markers of an increased mortality in hemodialysis patients. This study shows a positive association between serum leptin and lymphocytes, and a negative correlation between serum leptin and PMN. Leptin might have a protective role in decreasing mortality in hemodialysis patients by maintaining the function of the immune system.

Item Type: Article
Uncontrolled Keywords: end-stage renal failure; hemodialysis; serum leptin; lymphocyte percentage; white-blood cell count; reverse epidemiology
Subjects: WH Hemic and Lymphatic System
WJ Urogenital System
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Depositing User: zahra bagheri .
Date Deposited: 20 Aug 2017 03:06
Last Modified: 20 Aug 2017 03:06
URI: http://eprints.skums.ac.ir/id/eprint/3170

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