Hojjati, M.R. and van Woerden, G.M. and Tyler, W.J. and Giese, K.P. and Silva, A.J. and Pozzo-Miller, L. and Elgersma, Y. (2007) Kinase activity is not required for alpha CaMKII-dependent presynaptic plasticity at CA3-CA1 synapses. NATURE NEUROSCIENCE, 10 (9). pp. 1125-1127.
Full text not available from this repository.Abstract
Using targeted mouse mutants and pharmacologic inhibition of alpha CaMKII, we demonstrate that the aCaMKII protein, but not its activation, autophosphorylation or its ability to phosphorylate synapsin I, is required for normal short-term presynaptic plasticity. Furthermore, aCaMKII regulates the number of docked vesicles independent of its ability to be activated. These results indicate that aCaMKII has a nonenzymatic role in short-term presynaptic plasticity at hippocampal CA3-CA1 synapses.
| Item Type: | Article |
|---|---|
| Subjects: | WL Nervous system WM Psychiatry |
| Divisions: | Faculty of Medicine > Basic Sciences Academic Groups > Department of Physiology |
| Depositing User: | zahra bagheri . |
| Date Deposited: | 19 Aug 2017 08:03 |
| Last Modified: | 19 Aug 2017 08:03 |
| URI: | http://eprints.skums.ac.ir/id/eprint/3161 |
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