An association between Schistosoma mansoni worms and an enzymatically-active protease/peptidase in mouse blood

Darani, H.Y. and Doenhoff, M.J. (2008) An association between Schistosoma mansoni worms and an enzymatically-active protease/peptidase in mouse blood. PARASITOLOGY, 135 (4). pp. 467-472.

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Abstract

An enzyme found previously in extracts of adult Schistosoma mansoni Worms, that hydrolysed the chromogenic substrate N-acetyl-DL-phenylalanine beta-naphthyl -ester, has here been further investigated and characterized. Evidence that the molecule found in the parasite was antigenically and enzymatically homologous with a constituent of normal mouse plasma has been consolidated using a monospecific serum in immunoelectrophoresis and Western immunoblotting. The molecular size of the enzyme was found to be approximately 70 kDa and it was inhibited by a serine protease inhibitor, but not by inhibitors of other classes of protease. The enzymatic activity found in normal mouse serum was also found in normal rat serum, but not in sera from several other mammalian species.

Item Type: Article
Uncontrolled Keywords: schistosome; Schistosoma mansoni; protease; esterase; naphthylamidase; mouse; rat; host; antigen; serum; immune evasion
Subjects: QU Biochemistry
QX Parasitology
Divisions: Faculty of Medicine
Depositing User: zahra bagheri .
Date Deposited: 19 Aug 2017 07:18
Last Modified: 19 Aug 2017 07:18
URI: http://eprints.skums.ac.ir/id/eprint/3156

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