Increased Levels of IL-10, IL-12, and IFN-gamma in Patients with Visceral Leishmaniasis

Khoshdel, Abolfazl. and Abdolvahab, Alborz. and Rosouli, Manoochehr. and Taheri, Ebi. and Kiany, Simin. and Javadian, M.H. (2009) Increased Levels of IL-10, IL-12, and IFN-gamma in Patients with Visceral Leishmaniasis. BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, 13 (1). pp. 44-46.


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Visceral leishmaniasis remains a serious public health problem in developing countries. Cytokines have a crucial role in the pathogenesis of this disease. We evaluated plasma levels of IL-10, IL-12 and IFN-gamma in 32 patients with active visceral lieshmaniasis, in 29 siblings of the patients and in 23 normal individuals in an endemic area to look for correlations between the clinical outcome of infection and the plasma cytokine levels. An analysis was made with a skin test and a quantitative sandwich enzyme immunoassay. Data were analyzed with the Mann Whitney test and the Kruskal Wallis test. The cytokine levels were significantly higher in the patients than in the control groups. We concluded that normalization of the plasma level of IFN-gamma can serve as a reliable parameter for considering the patient as cured.

Item Type: Article
Uncontrolled Keywords: Visceral leishmaniasis; interleukin; interferon
Subjects: WC Communicable Diseases > Tropical and parasitic Diseases
QU Biochemistry
Divisions: Faculty of Medicine
Reserach Vice-Chancellar Department
Depositing User: Users 1 not found.
Date Deposited: 19 Aug 2017 06:09
Last Modified: 04 Mar 2018 10:02

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