Hyperthermia dose-effect relationship in 420 patients with cervical cancer treated with combined radiotherapy and hyperthermia

Franckena, Martine. and Fatehi, Daryoush. and de Bruijne, Maarten. and Canters, Richard.A.M. and van Norden, Yvette. and Mens, Jan Willem. and van Rhoon, Gerard.C. and Van Der Zee, Jacoba. (2009) Hyperthermia dose-effect relationship in 420 patients with cervical cancer treated with combined radiotherapy and hyperthermia. EUROPEAN JOURNAL OF CANCER, 45 (11). pp. 1969-1978.


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Adding hyperthermia to standard radiotherapy (RT + HT) improves treatment outcome for patients with locally advanced cervical cancer (LACC). We investigated the effect of hyperthermia dose on treatment outcome for patients with LACC treated with RT + HT. We collected treatment and outcome data of 420 patients with LACC treated with hyperthermia at our institute from 1990 to 2005. Univariate and multivariate analyses were performed on response rate, local control, disease-specific survival and toxicity for these patients to search for a thermal dose response relationship. Besides commonly identified prognostic factors in LACC like tumour stage, performance status, radiotherapy dose and tumour size, thermal parameters involving both temperature and duration of heating emerged as significant predictors of the various end-points. The more commonly used CEM43T90 (cumulative equivalent minutes of T90 above 43 degrees C) was less influential than TRISE (based on the average T50 increase and the duration of heating, normalised to the scheduled duration of treatment). CEM43T90 and TRISE measured intraluminally correlate significantly and independently with tumour control and survival. These findings stimulate further technological development and improvement of deep hyperthermia, as they strongly suggest that it might be worthwhile to increase the thermal dose for LACC, either by treatment optimisation or by prolonging the treatment time. These results also confirm the beneficial effects from hyperthermia as demonstrated in our earlier randomised trial, and justify applying radiotherapy and hyperthermia as treatment of choice for patients with advanced cervical cancer. (c) 2009 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Radiotherapy; Hyperthermia; Locally advanced cervical cancer; Thermal dose
Subjects: WJ Urogenital System
QZ pathology-Neoplasms
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Medical Physics
Depositing User: Users 1 not found.
Date Deposited: 19 Aug 2017 05:43
Last Modified: 08 May 2018 05:36
URI: http://eprints.skums.ac.ir/id/eprint/3140

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