Effects of spironolactone on proteinuria of patients with type 2 diabetes

Horestani, M and Behradmanesh, S. and Momeni, A. and Baradaran, A. (2012) Effects of spironolactone on proteinuria of patients with type 2 diabetes. Journal of Isfahan Medical School, 30 (200).

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Background: Diabetic nephropathy is the most common cause of kidney failure. We investigated the beneficial effects of spironolactone, alone and in combination with hydrochlorothiazide, on diabetic nephropathy. Methods: This randomized clinical trial was conducted on 60 type 2 diabetic patients with nephropathy. The patients were allocated to three groups of 20 to receive spironolactone (50 mg/d) plus placebo, spironolactone (50 mg/d) plus hydrochlorothiazide (25 mg/d), or placebo plus hydrochlorothiazide (25 mg/d). The duration of the study was three months. Measurements of 24-hour urine protein and other markers were performed at start and end of the study. Findings: Of 60 patients, 43 were male. The mean age of patients was 56.8 ± 8.3 years. The three groups were homogeneous regarding general factors. At the end of the study, a significant difference in proteinuria was observed between the groups. In the groups that received spironolactone, the mean 24-hour urine protein was reduced (200 mg/24h). However, there was no significant change in the last group. The mean serum potassium in the first group showed a significant increase (0.26 meq/l). However, there were no significant increases in the second and third groups. Conclusion: This investigation showed that spironolactone plus hydrochlorothiazide had a significant effect on reducing proteinuria without causing hyperkalemia and renal failure in patients with glomerular filtration rate > 50 cc/min. Therefore, spironolactone can serve as a renoprotective drug in diabetic nephropathy.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: hydrochlorothiazide; placebo; spironolactone, adult; Article; controlled study; diabetic nephropathy; female; glomerulus filtration rate; human; hyperkalemia; kidney failure; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; potassium blood level; proteinuria; randomized controlled trial; renal protection
Subjects: WD Nutrition Disease and metabolic diseases
WJ Urogenital System
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Depositing User: Users 1 not found.
Date Deposited: 15 Aug 2017 07:20
Last Modified: 15 Aug 2017 07:20
URI: http://eprints.skums.ac.ir/id/eprint/3065

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