The -514C/T polymorphism of hepatic lipase gene among iranian patients with coronary heart Disease

Ghatreh Samani, K. and Noori, M. and Rohbani Nobar, M. and Hashemzadeh Chaleshtory, M. and Farrokhi, E. and Darabi Amin, M. (2012) The -514C/T polymorphism of hepatic lipase gene among iranian patients with coronary heart Disease. Iranian Journal of Public Health, 41 (1). pp. 59-65.


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Background: The T allele of the hepatic lipase (HL) C-514T polymorphism was previously found to be associated with lower plasma HL activity. Here, we examined the association between this polymorphism and plasma HDL-cholesterol concentrations in patients with coronary arteries stenosis. Methods: We studied 342 subjects undergoing coronary angiography in two groups of non CAD (n=146) and CAD (n=196). -514C→T polymorphism was determined using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results: After adjustment for age, smoking and body mass index, HDL-cholesterol concentrations were significantly higher in men with the C/T&T/T genotype than those with the C/C genotype(mean 38.6 and 34.7 respectively P=0.01). The frequency of T allele in non CAD was 0.136 and 0.226 in female and male respectively and 0.170 and 0.223 for female and male in CAD subjects. There was no difference in T allele frequency in CAD and none CAD groups in male and female (P=0.466 and 0.722 respectively). Conclusion: -514C→T of LIPC gene have a positive effect on HDL-C concentration especially in male gender. However, no difference was determined in frequency of T allele between CAD and normal arteries subjects.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: Hepatic lipase gene, HDL-C, Coronary artery stenosis, T allele, Iran
Subjects: WG Cardiovascular System
QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Biochemistry and Genetics
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: Users 1 not found.
Date Deposited: 15 Aug 2017 08:09
Last Modified: 15 Aug 2017 08:09

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