Clinical and bacteriologic correlates of the papG alleles among uropathogenic Escherichia coli strains isolated from cases of adult urinary tract infection

Zamanzad, Behnam. and Karimi, Ali. and Nafisi, Mohammad Reza. and shirzad, Hedayatollah. (2012) Clinical and bacteriologic correlates of the papG alleles among uropathogenic Escherichia coli strains isolated from cases of adult urinary tract infection. Kuwait Medical Journal, 44 (1). pp. 26-29.

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Abstract

Objectives: To study the distribution of papG gene in uropathogenic Escherichia coli (E.coli) strains isolated from adult urinary tract infection (UTI) and the relationship between the different classes of papG gene and patients, sex, hospitalization and their clinical forms of UTI Design: Laboratory study Setting: Inpatient and outpatient settings with laboratory investigation Subjects and Methods: Genotyping of papG, the adhesin gene of E. coli P fimbriae, may predict clinical outcomes of UTI. A total of 182 urinary E.coli strains were analyzed by multiplex PCR method for detection of papG gene. Patients, sex, hospitalization and their clinical forms of UTI were also evaluated. Intervention: The distribution of papG gene in uropathogenic E.coli strains and the relationship between papG gene and clinical features of the patients Main Outcome Measures: Multiplex PCR method was performed for detection of papG gene in uropathogenic E.coli strains isolated from adult urinary tract infections Results: The prevalence of pap operon in the uropathogenic isolates was 36.2. The prevalence of papG gene classes II and III in uropathogenic isolates was 23.1 and 6.6 respectively. None of the isolates had class I genotype. PapG classes II and III were predominant in patients with pyelonephritis and cystitis respectively. There was no significant relationship between the presence of papG alleles, sex and hospitalization of the patients. Conclusions: PapG gene is likely to play an important role in pathogenesis of uropathogenic strains of E.coli in adult nosocomial UTIs. Detection and genotyping of this gene may contribute to improving the management of UTI.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: article; bacterial gene; bacterial strain; bacterial virulence; bacterium isolation; cystitis; Escherichia coli; female; gene frequency; gene function; gene identification; genotype; hospital patient; human; major clinical study; male; multiplex polymerase chain reaction; nonhuman; operon; outpatient; PapG gene; pyelonephritis; urinary tract infection
Subjects: WC Communicable Diseases > Infection.Bacterial Infections
WJ Urogenital System
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 15 Aug 2017 09:07
Last Modified: 06 Feb 2018 10:48
URI: http://eprints.skums.ac.ir/id/eprint/3050

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