Effect of silymarin on liver phoshpatidate phosphohydrolase in hyperlipidemic rats

Heidarian, E. and Rafieian-Kopaei, M. (2012) Effect of silymarin on liver phoshpatidate phosphohydrolase in hyperlipidemic rats. Bioscience Research, 9 (2). pp. 59-67.


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Previous studies have shown that silymarin, a flavonoid antioxidant, possesses a hypolipidemic effect. The aim of this study was to evaluate the effect of silymarin on liver phoshpatidate phosphohydrolase, total plasma cholesterol, plasma lipoproteins, liver and plasma triglyceride, plasma malondialdehyde, and plasma antioxidant in rats fed with high cholesterol diet enriched with fat. Male rats were fed by standard pellet diet (group I), standard diet accompanied with silymarin (group II), lipogenic diet (containing saturated fat, cholesterol and ethanol) plus silymarin (group III), and only lipogenic diet (group IV). On day 60 of the experiment, liver phosphatidate phosphohydrolase activity, liver triglyceride, plasma lipids, plasma malondialdehyde, and plasma antioxidant levels were measured. Group II showed a significant reduction (20) (p < 0.001) in the liver PAP activity compared to group I. The atherogenic ratio of total cholesterol to high density lipoprotein cholesterol, liver triglyceride, plasma total cholesterol, and triglyceride levels significantly decreased (p < 0.05) due to silymarin treatment in group III compared to group IV. Significant reduction in plasma malondialdehyde (p < 0.05) and significant elevation (p < 0.05) in plasma antioxidant power observed in group III compared to group IV. These results clearly suggested that silymarin can be effective to reducing liver phosphatidate phosphohydrolase activity and liver triglyceride. Furthermore, silymarin had blood lipid-reducing and beneficial antioxidant effects in hyperlipidemic diets. © ISISnet Publishers.

Item Type: Article
Additional Information: cited By
Uncontrolled Keywords: Hyperlipidemia, liver triglyceride, plasma lipids, phosphatidate phosphohydrolase, silymarin.
Subjects: WK Endocrine System
QU Biochemistry
QV pharmacology > QV 704 Pharmaceutics
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 15 Aug 2017 06:22
Last Modified: 15 Aug 2017 06:22
URI: http://eprints.skums.ac.ir/id/eprint/2999

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