Serum cholesterol and LDL-C in association with level of diastolic blood pressure in type 2 diabetic patients.

Behradmanesh, Saeed. and Nasri, Parto. (2012) Serum cholesterol and LDL-C in association with level of diastolic blood pressure in type 2 diabetic patients. Journal of renal injury prevention, 1 (1). pp. 23-6. ISSN 2345-2781

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Abstract

INTRODUCTION Elevated cholesterol and blood pressure are major risk factors for the development diabetic kidney disease. Possible interactions between these two parameters have not been studied in detail. OBJECTIVES This investigation aims to study the values of blood serum cholesterol, blood pressure and possible correlations between them, in a group of type 2 diabetic (T2D) patients. PATIENTS AND METHODS A total of 60 patients with T2D were enrolled to the study. Venous blood samples were obtained in the fasting state for determinations of serum creatinine, lipids and hemoglobin A1C (HbA1c). RESULTS Of 60 participants, Mean of age was 57±8.3 years. Mean of systolic and diastolic blood pressure was 133±13 mmHg and 84±7.4 mmHg respectively. Mean of serum cholesterol and LDL-C was 182±34.5 mg/dl and 97.2 ±27.9 mg/dl respectively. In this study, a significant positive correlation of serum cholesterol with level of diastolic blood pressure (r= 0.286, p=0.030) was seen (adjusted for duration of diabetes and weight). Furthermore a significant positive correlation of serum LDL-C with level of diastolic blood pressure (r= 0.263, p= 0.044) was seen (adjusted for age). CONCLUSION We found a significant inverse correlation of serum cholesterol and LDL-C with level of diastolic blood pressure. This study showed the influence of serum lipids on the development of hypertension and further support the control of dyslipidemia, to prevent diabetic kidney disease.

Item Type: Article
Uncontrolled Keywords: Cholesterol Blood pressure Dyslipidemia Type 2 diabetes Hypertension Diabetic nephropathy Lipids
Subjects: WD Nutrition Disease and metabolic diseases
WG Cardiovascular System
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 15 Aug 2017 05:12
Last Modified: 30 May 2018 08:19
URI: http://eprints.skums.ac.ir/id/eprint/2968

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