The renal toxicity of hydroalcoholic extract of Stachys lavandulifolia Vahl in Wistar rats

Taghikhani, Mohammad. and Nasri, Hamid. and Asgari, Azam. and Afrough, H. and Namjoo, Abdolrasoul. and Ansari Samani, Roya. and Shahinfard, Najmeh. and Rafieian-Kopaei, Mahmoud. (2012) The renal toxicity of hydroalcoholic extract of Stachys lavandulifolia Vahl in Wistar rats. LIFE SCIENCE JOURNAL-ACTA ZHENGZHOU UNIVERSITY OVERSEAS EDITION, 9 (4). pp. 3025-3031.

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Abstract

Stachys lavandulifolia is used as the herbal tea in gastrointestinal disorders. It is believed that this plant has beneficial curative properties. However, more studies are needed to determine the toxic effects of plant. The aim of this study was to evaluate the nephrotoxicity of hydro-alcoholic extract of Stachys lavandulifolia Vahl on male Wistar rats. In this experimental study, 100 adult male Wistar rats (200-250 g) were divided into 5 groups of 20; including one control and 4 experimental groups, and injected i.p saline or Stachys lavandulifolia Vahl extract (50,100,150 and 200 mg/kg) for 1 month. Then sampling was done from half of the animas of each group. The left animals in each group were held without injection for one more month and then sampling was done. In the groups that Stachys lavandulifolia Vahl extract were used for one month, a mild degeneration of renal tubular epithelial cell was observable. However, in the second month of the study, the histologic lesions were significantly more (P<0.05). Stachys lavandulifolia Vahl extract has renal tubular toxicity and this toxicity may continue even following drug discontinuation. However, further studies need to evaluate renal complications of this drug in human. Taghikhani M, Nasri H, Asgari A, Afrough H, Namjoo AR, Ansari-Samani R, Shahinfard N and Rafieian-kopaei. The renal toxicity of hydro-alcoholic extract of Stachys lavandulifolia Vahl in Wistar rats. Life Sci J 2012;9(4):3025-3031] (ISSN:1097-8135). http://www.lifesciencesite.com. 444

Item Type: Article
Uncontrolled Keywords: Lamiaceae family; Therapeutic properties; Renal toxicity; Tubular degeneration
Subjects: WJ Urogenital System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 14 Aug 2017 09:16
Last Modified: 30 May 2018 08:22
URI: http://eprints.skums.ac.ir/id/eprint/2918

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